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Mechanism of Toxic Action on Some Target Organs

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Table of Contents

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    Book Overview
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    Chapter 1 Young Scientists Award Lecture 1978: Studies on the Role of Acetylhydrazine in Isoniazid Hepatotoxicity
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    Chapter 2 Evaluation of Effects of Sexual Steroids on the Hypothalamic-Pituitary System of Animals and Man
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    Chapter 3 Ultrastructure of Intermediate Lobe of the Pituitary and Melanocyte-Stimulating Hormone Secretion in Oestrogen-Induced Kidney Tumours in Male Hamsters
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    Chapter 4 Role of Neuroendocrine System in Regulation of Mammary Tumors in Different Species
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    Chapter 5 Evaluation of the Carcinogenic Effects of Estrogens, Progestins and Oral Contraceptives on Cervix, Uterus and Ovary of Animals and Man
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    Chapter 6 Assessment of ACTH-Adrenal Activity After Treatment with a Glucocorticoid and an Antiandrogenic Steroid
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    Chapter 7 Neuroendocrine Effects of Neuropsychotropic Drugs and Their Possible Influence on Toxic Reactions in Animals and Man — The Role of the Dopamine-Prolactin System
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    Chapter 8 Motility and Stereotyped Behaviour Induced by Amphetamine and Apomorphine on Hypophysectomized and on Thyroidectomized Rats
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    Chapter 9 Adaptive Liver Growth Induced by Xenobiotic Compounds: Its Nature and Mechanism
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    Chapter 10 Growth Control in Regenerating Rat Liver
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    Chapter 11 Control of Liver Growth by Growth Inhibitors (Chalones)
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    Chapter 12 Nucleic Acid and Pyrimidine Nucleotide Metabolism During Liver Growth Induced by Xenobiotic Compounds
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    Chapter 13 Early Biological Markers During Liver Carcinogenesis
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    Chapter 14 Correlation of Liver Growth and Function During Liver Regeneration and Hepatocarcinogenesis
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    Chapter 15 Liver Growth and Tumorigenesis in Rats
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    Chapter 16 Liver Tumors and Steroid Hormones in Rats and Mice
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    Chapter 17 The Effects of Dieldrin, Diet and Other Environmental Components on Enzyme Function and Tumour Incidence in Livers of CF-1 Mice
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    Chapter 18 Enzymes as Regulators of Toxic Reactions by Electrophilic Metabolites
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    Chapter 19 Pharmacokinetic Parameters Influencing Tissue Specificity in Chemical Carcinogenesis
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    Chapter 20 Organ Specificity of Induction of Activating and Inactivating Enzymes by Cigarette Smoke and Cigarette Smoke Condensate
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    Chapter 21 DNA Repair as Regulatory Factor in the Organotropy of Alkylating Carcinogens
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    Chapter 22 Physiological Mechanisms of Diethylstilbestrol Organotropic Carcinogenesis
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    Chapter 23 Diethylstilbestrol Metabolic Transformation in Relation to Organ Specific Tumor Manifestation
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    Chapter 24 Organotropic Mutagenesis in Tissues of Chinese Hamsters Induced by Chemical Carcinogens
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    Chapter 25 Modulation of the in vivo Covalent Binding of the Carcinogen Benzo(a)pyrene to Rat Liver DNA by Selective Induction of Microsomal and Nuclear Aryl Hydrocarbon Hydroxylase Activity
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    Chapter 26 Estimation of the TCDD Toxic Potential in the Light of the Seveso Accident
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    Chapter 27 Biological Threshold Limits for Benzene Based on Pharmacokinetics of Inhaled Benzene in Man
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    Chapter 28 Short Term Effects of Clophen A 50 and of Dichlorobiphenyl in Rats
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    Chapter 29 Toxic Effects of Di-n-octyltin Dichloride on the Thymus in Mice
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    Chapter 30 2-Hydroxyoestradiol and (+)-Cyanidanol-3 Prevent Lipid Peroxidation of Isolated Rat Hepatocytes
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    Chapter 31 Accentuation of White Phosphorus Induced Fatty Liver by Phenobarbitone in Male Rats Compared to Female Rats
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    Chapter 32 Fatty Liver Induced by High Doses of Rifampicin in the Rat: Possible Relation with an Inhibition of RNA Polymerases in Eukariotic Cells
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    Chapter 33 An Experimental Model for the Study of Hepatic Transport and Metabolism of Toxic Compounds
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    Chapter 34 Effects of Subacute Toluene Inhalation on its Metabolism and Disposition in Rat
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    Chapter 35 Drug-Nitrite Interactions: Species and Sex Differences in the Formation of Dimethylnitrosamine and its Effects on the Hepatic Enzyme Activities
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    Chapter 36 Monoamine Oxidase Inhibiting and Toxic Effects of Acetyl-Phenylhydrazide on Rat Liver in Vivo
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    Chapter 37 Side Effects of Colloidal Plasmasubstitutes on Hemostasis in Patients with Terminal Renal Failure
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    Chapter 38 Accelerated Renal Elimination of Thallium in the Rat Due to Treatment with Furosemide or Potassium Ions
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    Chapter 39 Entrance into Brain of Dextropropoxyphene and the Toxic Metabolite Norpropoxyphene
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    Chapter 40 Comparison of the Acute Toxicity of Clioquinol, Histamine, and Chloroform in Different Strains of Mice
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    Chapter 41 Prostaglandins in Rat Placenta Following Acute and Chronic Administration of Morphine
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    Chapter 42 Effects of Two Structurally Different Antispermatogenic Compounds on the Synthesis of Steroids in Rat Testes
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    Chapter 43 Ultrastructural Alterations Induced by Two Different Antispermatogenic Agents in the Seminiferous Epithelium of Rat Testes
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    Chapter 44 Therapeutic Effects of the Bis-Pyridinium Salts HGG-12, HGG-42, and Atropine, Benactyzine in Organophosphate Poisoning of Dogs
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    Chapter 45 Hormonal Control of Prothrombin Synthesis in Rat Liver Microsomes, with Special Reference to the Role of Estradiol, Testosterone and Prolactin
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    Chapter 46 Lifespan studies on male and female mice and rats under SPF-laboratory conditions.
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    Chapter 47 The Loss of Creatine Phosphokinase (CK) from Intramuscular Injection Sites in Rabbits
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    Chapter 48 In vivo Covalent Binding of Chemicals to DNA as a Short-Term Test for Carcinogenicity
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    Chapter 49 A Dynamic System for Long-Term Toxicity Studies in Fish Under Laboratory Conditions
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    Chapter 50 Effect of Intratracheal and Oral Application of Corticosteroids on the Adrenal Function Test in Beagle Dogs After ACTH-Stimulation
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    Chapter 51 Drug Actions in Rats with Arteriosclerosis Induced by Toxic Doses of Vitamin D 2
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    Chapter 52 Apparent Tropism of a Vasodilator, Mecinarone, for Melanin-Containing Tissues and Activation of Melanogenesis in the Beagle
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    Chapter 53 Estrogenic Partial Effect of Norethisterone Enanthate in Relation to Tumor Induction in Rat Mammary Gland
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    Chapter 54 The Special Suitability of Inbred Syrian Hamsters for Carcinogenesis Testing
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    Chapter 55 Proliferation of Rat Liver Cells in Preneoplastic Nodules After Stimulation of Liver Growth by Xenobiotic Inducers
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    Chapter 56 The Regulative Role of Food Consumption in the Induction of Rat Liver Cell Proliferation by Drugs and Environmental Pollutants
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    Chapter 57 Induction of Pre-Malignant Hepatic Lesions: Comparative Effects of Vinyl Chloride and Trichloroethylene
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    Chapter 58 Microsomal Vinyl Oxide Synthetase: Modification of its Kinetic Parameters by Chemical Carcinogens
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    Chapter 59 Influence of Drugs on Activation and Inactivation of Hepatocarcinogenic Nitrosamines
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    Chapter 60 Effect of DMN, Phenobarbital and Halothane on the Sedimentation Characteristics of Rat Liver DNA
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    Chapter 61 Activities of polycyclic hydrocarbon activating and inactivating enzymes in human lungs of smokers, non-smokers, lung-cancer and non-cancer patients. - PubMed - NCBI
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    Chapter 62 Demonstration of Drug-Ethanol Interactions by Changes in Activity of Hepatic Microsomal Oxidase/Oxygenase Cytochrome P-450 Function
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    Chapter 63 Alcohol and Aldehyde Dehydrogenase on Chronic Ethanol Intoxication
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    Chapter 64 Polycystic Changes in Rat Kidney Induced by Biphenyl Fed in Different Diets
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    Chapter 65 Unscheduled DNA Synthesis in Male Rabbit Germ Cells Induced by Methylmethane Sulfonate, Cyclophosphamide and Adriamycin
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    Chapter 66 Plasma Proteins — Animal Assays on Possible Cardiovascular Side-Effects
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    Chapter 67 Exploitation of Toxicological Results and its Problems
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    Chapter 68 Computer Analysis and Integration of Animal Pathology Data
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Title
Mechanism of Toxic Action on Some Target Organs
Published by
Springer Berlin Heidelberg, March 2013
DOI 10.1007/978-3-642-67265-1
ISBNs
978-3-54-009305-3, 978-3-64-267265-1
Editors

Chambers, Philip L., Günzel, Peter