Chapter title |
The role of lactic acidosis in the ischemic nerve cell injury.
|
---|---|
Chapter number | 6 |
Book title |
Experimental and Clinical Neuropathology
|
Published in |
Acta neuropathologica Supplementum, January 1981
|
DOI | 10.1007/978-3-642-81553-9_6 |
Pubmed ID | |
Book ISBNs |
978-3-54-010449-0, 978-3-64-281553-9
|
Authors |
Kalimo, H, Rehncrona, S, Söderfeldt, B, Hannu Kalimo, S. Rehncrona, B. Söderfeldt, Kalimo, Hannu, Rehncrona, S., Söderfeldt, B. |
Abstract |
Severe incomplete cerebral ischemia of 30 min duration with CBF below 5% of normal was induced in rats by clamping both carotids and lowering BP. One group of rats were fasting (f-rats), while the other was infused with glucose before induction of the ischemia (g-rats). In f-rats the lactate accumulating in the cerebral cortex was about 15 mumol . g-1, whereas in g-rats it rose to about 35 mumol . g-1. In f-rats considerable recovery of the energy state and electrical activity occurred during recirculation, whereas in g-rats the energy failure persisted with no electrical activity reappearing. In f-rats the structural alterations were of minor severity, but in g-rats extensive progressive tissue damage was seen. The data indicate that the degree of tissue lactic acidosis has pronounced effects on the development of irreversible ischemic nerve cells injury. |
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