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Transformative Concepts for Drug Design: Target Wrapping

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Cover of 'Transformative Concepts for Drug Design: Target Wrapping'

Table of Contents

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    Book Overview
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    Chapter 1 Protein Cooperativity and Wrapping: Two Themes in the Transformative Platform of Molecular Targeted Therapy
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    Chapter 2 Wrapping Defects and the Architecture of Soluble Proteins
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    Chapter 3 Folding Cooperativity and the Wrapping of Intermediate States of Soluble Natural Proteins
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    Chapter 4 Wrapping Deficiencies and De-wetting Patterns in Soluble Proteins: A Blueprint for Drug Design
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    Chapter 5 Under-Wrapped Proteins in the Order–Disorder Twilight: Unraveling the Molecular Etiology of Aberrant Aggregation
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    Chapter 6 Evolution of Protein Wrapping and Implications for the Drug Designer
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    Chapter 7 Wrapping as a Selectivity Filter for Molecular Targeted Therapy: Preliminary Evidence
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    Chapter 8 Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects
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    Chapter 9 Wrapping Patterns as Universal Markers for Specificity in the Therapeutic Interference with Signaling Pathways
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    Chapter 10 Fulfilling a Therapeutic Imperative in Cancer Treatment: Control of Multi-target Drug Impact
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    Chapter 11 Inducing Folding By Crating the Target
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    Chapter 12 Wrapper Drugs as Therapeutic Editors of Side Effects
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    Chapter 13 Wrapper Drugs for Personalized Medicine
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    Chapter 14 Last Frontier and Back to the Drawing Board: Protein–Water Interfacial Tension in Drug Design
Attention for Chapter 8: Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects
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Chapter title
Re-engineering an Anticancer Drug to Make It Safer: Modifying Imatinib to Curb Its Side Effects
Chapter number 8
Book title
Transformative Concepts for Drug Design: Target Wrapping
Published by
Springer, Berlin, Heidelberg, January 2010
DOI 10.1007/978-3-642-11792-3_8
Book ISBNs
978-3-64-211791-6, 978-3-64-211792-3
Authors

Ariel Fernandez

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