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Antibody-Drug Conjugates

Overview of attention for book
Cover of 'Antibody-Drug Conjugates'

Table of Contents

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    Book Overview
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    Chapter 1 Antibody-Drug Conjugate (ADC) Clinical Pipeline: A Review.
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    Chapter 2 Antibody–Drug Conjugate Target Selection: Critical Factors
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    Chapter 3 Selecting an Optimal Antibody for Antibody–Drug Conjugate Therapy: Internalization and Intracellular Localization
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    Chapter 4 Antibody–Drug Conjugate Payloads
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    Chapter 5 Linker Technologies for Antibody–Drug Conjugates
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    Chapter 6 In Vivo Testing of Drug-Linker Stability
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    Chapter 7 Pharmacokinetics and ADME Characterizations of Antibody–Drug Conjugates
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    Chapter 8 Safe Handling of Cytotoxic Compounds in a Biopharmaceutical Environment
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    Chapter 9 Micro- and Mid-Scale Maleimide-Based Conjugation of Cytotoxic Drugs to Antibody Hinge Region Thiols for Tumor Targeting
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    Chapter 10 Protocols for Lysine Conjugation
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    Chapter 11 Engineering THIOMABs for Site-Specific Conjugation of Thiol-Reactive Linkers.
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    Chapter 12 Enzymatic antibody modification by bacterial transglutaminase.
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    Chapter 13 Formulation development of antibody-drug conjugates.
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    Chapter 14 Conjugation Process Development and Scale-Up
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    Chapter 15 Methods for Conjugating Antibodies to Nanocarriers
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    Chapter 16 Drug-to-Antibody Ratio (DAR) by UV/Vis Spectroscopy
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    Chapter 17 Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by Hydrophobic Interaction Chromatography and Reversed Phase High-Performance Liquid Chromatography
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    Chapter 18 Drug-to-Antibody Ratio (DAR) and Drug Load Distribution by LC-ESI-MS
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    Chapter 19 Determination of Charge Heterogeneity and Level of Unconjugated Antibody by Imaged cIEF
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    Chapter 20 Risk-Based Scientific Approach for Determination of Extractables/Leachables from Biomanufacturing of Antibody–Drug Conjugates (ADCs)
Attention for Chapter 13: Formulation development of antibody-drug conjugates.
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About this Attention Score

  • Good Attention Score compared to outputs of the same age (66th percentile)
  • Good Attention Score compared to outputs of the same age and source (68th percentile)

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Citations

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Chapter title
Formulation development of antibody-drug conjugates.
Chapter number 13
Book title
Antibody-Drug Conjugates
Published in
Methods in molecular biology, August 2013
DOI 10.1007/978-1-62703-541-5_13
Pubmed ID
Book ISBNs
978-1-62703-540-8, 978-1-62703-541-5
Authors

Galush WJ, Wakankar AA, William J. Galush, Aditya A. Wakankar, Galush, William J., Wakankar, Aditya A.

Abstract

Formulation development of an ADC resembles that of a conventional antibody, but the conjugated form introduces new molecular attributes such as drug-to-antibody ratio and stability of the drug itself that need to be considered. An extended set of analytical tools, coupled with understanding of how ADCs and conventional antibodies differ in terms of their stability, guides formulation selection.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 37 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Switzerland 1 3%
Unknown 36 97%

Demographic breakdown

Readers by professional status Count As %
Researcher 12 32%
Student > Ph. D. Student 5 14%
Student > Master 5 14%
Other 4 11%
Student > Bachelor 2 5%
Other 3 8%
Unknown 6 16%
Readers by discipline Count As %
Agricultural and Biological Sciences 9 24%
Chemistry 7 19%
Pharmacology, Toxicology and Pharmaceutical Science 4 11%
Biochemistry, Genetics and Molecular Biology 3 8%
Engineering 3 8%
Other 4 11%
Unknown 7 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 December 2021.
All research outputs
#8,128,001
of 25,090,809 outputs
Outputs from Methods in molecular biology
#2,455
of 14,110 outputs
Outputs of similar age
#65,886
of 203,618 outputs
Outputs of similar age from Methods in molecular biology
#17
of 54 outputs
Altmetric has tracked 25,090,809 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 14,110 research outputs from this source. They receive a mean Attention Score of 3.5. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,618 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 66% of its contemporaries.
We're also able to compare this research output to 54 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.