| Chapter title |
U-50,488 and the kappa receptor: a personalized account covering the period 1973 to 1990.
|
|---|---|
| Chapter number | 4 |
| Book title |
Progress in Drug Research
|
| Published in |
Fortschritte der Arzneimittelforschung Progress in drug research Progrès des recherches pharmaceutiques, January 1999
|
| DOI | 10.1007/978-3-0348-8730-4_4 |
| Pubmed ID | |
| Book ISBNs |
978-3-03-489746-4, 978-3-03-488730-4
|
| Authors |
J Szmuszkovicz, Szmuszkovicz, J, Szmuszkovicz, Jacob |
| Abstract |
All clinically significant analgesics for severe pain derive from the morphine model. Morphine has provided a fertile area for medicinal chemistry research and received an additional stimulus in the 1970s with the appearance of the opioid receptors. The background for the birth of U-50,488 is described herein. It occurred before the discovery of the kappa receptor and, thus, U-50,488 was classified originally as a non-mu compound, and only later as a kappa agonist. U-50,488 provided a succinct template for structural modifications and they are described for the period up to 1990. A description of the structural classes of kappa agonists is provided including a summary of kappa recognition sites based on known agonists. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 6 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 2 | 33% |
| Student > Bachelor | 1 | 17% |
| Student > Ph. D. Student | 1 | 17% |
| Unknown | 2 | 33% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 2 | 33% |
| Agricultural and Biological Sciences | 1 | 17% |
| Medicine and Dentistry | 1 | 17% |
| Unknown | 2 | 33% |