| Chapter title |
Discovery and utilization of biocatalysts for chiral synthesis: an overview of Chinese scientists' research and development.
|
|---|---|
| Chapter number | 30 |
| Book title |
Biotechnology in China I
|
| Published in |
Advances in biochemical engineering biotechnology, December 2008
|
| DOI | 10.1007/10_2008_30 |
| Pubmed ID | |
| Book ISBNs |
978-3-54-088414-9, 978-3-54-088415-6
|
| Authors |
Yu HL, Xu JH, Lu WY, Lin GQ, Hui-Lei Yu, Jian-He Xu, Wen-Ya Lu, Guo-Qiang Lin, Yu, Hui-Lei, Xu, Jian-He, Lu, Wen-Ya, Lin, Guo-Qiang |
| Abstract |
The importance of chiral issues in active pharmaceutical ingredients has been widely recognized not only by pharmacologists, but also by chemists, chemical engineers and administrators. In fact, the worldwide sales of single-enantiomer drugs have exceeded US $150 billion. Among them the contribution rate of biocatalysis technology is ever increasing (up to 15-20%). This chapter will focus on the biocatalytic synthesis of chiral compounds useful for pharmaceutical industry. Diverse enzymes, such as oxidoreductases, epoxide hydrolases, nitrilases/nitrile hydratases and hydroxy nitrile lyases which were isolated from various sources including microorganisms and plants, and the methodology for utilizing these enzymes in enantioselective or asymmetric synthesis will be discussed briefly. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Switzerland | 2 | <1% |
| Japan | 1 | <1% |
| Singapore | 1 | <1% |
| Brazil | 1 | <1% |
| Unknown | 361 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 17 | 5% |
| Student > Master | 16 | 4% |
| Researcher | 8 | 2% |
| Professor | 6 | 2% |
| Student > Doctoral Student | 6 | 2% |
| Other | 11 | 3% |
| Unknown | 302 | 83% |
| Readers by discipline | Count | As % |
|---|---|---|
| Business, Management and Accounting | 22 | 6% |
| Economics, Econometrics and Finance | 17 | 5% |
| Social Sciences | 7 | 2% |
| Computer Science | 4 | 1% |
| Chemistry | 4 | 1% |
| Other | 10 | 3% |
| Unknown | 302 | 83% |