| Chapter title |
Protein tyrosine phosphatases: structure, function, and implication in human disease.
|
|---|---|
| Chapter number | 13 |
| Book title |
Phosphatase Modulators
|
| Published in |
Methods in molecular biology, July 2013
|
| DOI | 10.1007/978-1-62703-562-0_13 |
| Pubmed ID | |
| Book ISBNs |
978-1-62703-561-3, 978-1-62703-562-0
|
| Authors |
Tautz L, Critton DA, Grotegut S, Lutz Tautz, David A. Critton, Stefan Grotegut, Tautz, Lutz, Critton, David A., Grotegut, Stefan |
| Abstract |
Protein tyrosine phosphorylation is a key regulatory mechanism in eukaryotic cell physiology. Aberrant expression or function of protein tyrosine kinases and protein tyrosine phosphatases can lead to serious human diseases, including cancer, diabetes, as well as cardiovascular, infectious, autoimmune, and neuropsychiatric disorders. Here, we give an overview of the protein tyrosine phosphatase superfamily with its over 100 members in humans. We review their structure, function, and implications in human diseases, and discuss their potential as novel drug targets, as well as current challenges and possible solutions to developing therapeutics based on these enzymes. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 112 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 17% |
| Student > Bachelor | 14 | 13% |
| Student > Master | 10 | 9% |
| Researcher | 8 | 7% |
| Unspecified | 7 | 6% |
| Other | 12 | 11% |
| Unknown | 42 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 18% |
| Agricultural and Biological Sciences | 17 | 15% |
| Chemistry | 9 | 8% |
| Unspecified | 7 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 4% |
| Other | 12 | 11% |
| Unknown | 43 | 38% |