Chapter title |
Are metabolites of l-deprenyl (selegiline) useful or harmful? Indications from preclinical research.
|
---|---|
Chapter number | 6 |
Book title |
Deprenyl — Past and Future
|
Published in |
Journal of neural transmission Supplementum, January 1996
|
DOI | 10.1007/978-3-7091-7494-4_6 |
Pubmed ID | |
Book ISBNs |
978-3-21-182891-5, 978-3-70-917494-4
|
Authors |
S Yasar, J P Goldberg, S R Goldberg, S. Yasar, J. P. Goldberg, Dr. S. R. Goldberg, S. R. Goldberg, Yasar, S., Goldberg, J. P., Goldberg, S. R. |
Abstract |
A frequent topic of controversy has been whether metabolism of l-deprenyl (selegiline) to active metabolites is a detriment to clinical use. This paper reviews possible roles of the metabolites of l-deprenyl in producing unwanted adverse side effects or in augmenting or mediating its clinically useful actions. Levels of l-amphetamine and l-methamphetamine likely to be reached, even with excessive intake of l-deprenyl, would be unlikely to produce neurotoxicity and there is no preclinical or clinical evidence of abuse liability of l-deprenyl. In contrast, there is evidence that l-amphetamine and l-methamphetamine have some qualitatively different actions than their d-isomer counterparts on EEG and cognitive functioning which might result in beneficial clinical effects and complement beneficial clinical actions of l-deprenyl itself. |
X Demographics
Geographical breakdown
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 2 | 13% |
Other | 2 | 13% |
Student > Doctoral Student | 1 | 7% |
Student > Bachelor | 1 | 7% |
Unspecified | 1 | 7% |
Other | 4 | 27% |
Unknown | 4 | 27% |
Readers by discipline | Count | As % |
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Neuroscience | 3 | 20% |
Social Sciences | 2 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 7% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Psychology | 1 | 7% |
Other | 3 | 20% |
Unknown | 4 | 27% |