Report for: Vascular Morphogenesis

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Chapter title	The corneal pocket assay.
Chapter number	2
Book title	Vascular Morphogenesis
Published in	Methods in molecular biology, January 2015
DOI	10.1007/978-1-4939-1462-3_2
Pubmed ID	25468596
Book ISBNs	978-1-4939-1461-6, 978-1-4939-1462-3
Authors	Marina Ziche, Lucia Morbidelli, Ziche, Marina, Morbidelli, Lucia
Abstract	The cornea in most species is physiologically avascular, and thus this assay allows the measurement of newly formed vessels. The continuous monitoring of neovascular growth in the same animal allows the evaluation of drugs acting as suppressors or stimulators of angiogenesis. Under anesthesia a micropocket is produced in the cornea thickness and the angiogenesis stimulus (tumor tissue, cell suspension, growth factor) is placed into the pocket in order to induce vascular outgrowth from the limbal capillaries. Neovascular development and progression can be modified by the presence of locally released or applied inhibitory factors or by systemic treatments. In this chapter the experimental details of the avascular cornea assay, the technical challenges, and advantages and disadvantages in different species are discussed. Protocols for local drug treatment and tissue sampling for histology and pharmacokinetic profile are reported.

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Mendeley readers

The data shown below were compiled from readership statistics for 12 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Unknown	12	100%

Demographic breakdown

Readers by professional status	Count	As %
Researcher	4	33%
Student > Ph. D. Student	2	17%
Unspecified	1	8%
Professor > Associate Professor	1	8%
Student > Postgraduate	1	8%
Other	0	0%
Unknown	3	25%

Readers by discipline	Count	As %
Agricultural and Biological Sciences	3	25%
Medicine and Dentistry	2	17%
Pharmacology, Toxicology and Pharmaceutical Science	1	8%
Biochemistry, Genetics and Molecular Biology	1	8%
Unspecified	1	8%
Other	0	0%
Unknown	4	33%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 04 December 2014.

All research outputs

#20,245,139

of 22,772,779 outputs

Outputs from Methods in molecular biology

#9,863

of 13,090 outputs

Outputs of similar age

#295,638

of 352,917 outputs

Outputs of similar age from Methods in molecular biology

#635

of 996 outputs

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So far Altmetric has tracked 13,090 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.

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Vascular Morphogenesis

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Demographic breakdown

Attention Score in Context