Cell Culture Engineering IV

Table of Contents

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   Book Overview
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   Chapter 1 Introduction
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   Chapter 2 Cultural and physiological factors affecting expression of recombinant proteins
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   Chapter 3 Selecting and designing cell lines for improved physiological characteristics
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   Chapter 4 Applications of improved stoichiometric model in medium design and fed-batch cultivation of animal cells in bioreactor
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   Chapter 5 Diverse effects of essential ( n -6 and n -3) fatty acids on cultured cells
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   Chapter 6 Enhancement effects of BSA and linoleic acid on hybridoma cell growth and antibody production
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   Chapter 7 Growth rate suppression of cultured mammalian cells enhances protein productivity
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   Chapter 8 Growth and interferon-γ production in batch culture of CHO cells
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    Chapter 9 Metabolic and kinetic studies of hybridomas in exponentially fed-batch cultures using T-flasks
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    Chapter 10 Adaptation of mammalian cells to non-ammoniagenic media
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    Chapter 11 Effect of endogenous proteins on growth and antibody productivity in hybridoma batch cultures
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    Chapter 12 Extracellular insulin degrading activity creates instability in a CHO-based batch-refeed continuous process
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    Chapter 13 Low temperature cultivation — A step towards process optimisation
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    Chapter 14 Induction of apoptosis in oxygen-deprived cultures of hybridoma cells
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    Chapter 15 Maximization of recombinant protein yield in the insect cell/baculovirus system by one-time addition of nutrients to high-density batch cultures
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    Chapter 16 Recombinant protein expression in a Drosophila cell line: comparison with the baculovirus system
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    Chapter 17 Scale-up of the adenovirus expression system for the production of recombinant protein in human 293S cells
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    Chapter 18 Relationship between oxygen uptake rate and time of infection of Sf9 insect cells infected with a recombinant baculovirus
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    Chapter 19 Optimization of vaccine production for animal health
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    Chapter 20 Evaluation of monitoring approaches and effects of culture conditions on recombinant protein production in baculovirus-infected insect cells
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    Chapter 21 The analysis of protein pharmaceuticals: Near future advances
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    Chapter 22 The effect of protein synthesis inhibitors on the glycosylation site occupancy of recombinant human prolactin
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    Chapter 23 Effect of lipid supplements on the production and glycosylation of recombinant interferon-γ expressed in CHO cells
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    Chapter 24 Role of environmental conditions on the expression levels, glycoform pattern and levels of sialyltransferase for hFSH produced by recombinant CHO cells
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    Chapter 25 Glycosylation and functional activity of anti-D secreted by two human lymphoblastoid cell lines
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    Chapter 26 Interaction of cell culture with downstream purification: a case study
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    Chapter 27 Evaluation of membranes for use in on-line cell separation during mammalian cell perfusion processes
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    Chapter 28 Vortex flow filtration of mammalian and insect cells
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    Chapter 29 Automated imunoanalysis systems for monitoring mammalian cell cultivation processes
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    Chapter 30 A direct computer control concept for mammalian cell fermentation processes
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    Chapter 31 Automated monitoring of cell concentration and viability using an image analysis system
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    Chapter 32 Software sensors for the monitoring of perfusion cultures: Evaluation of the hybridoma density and the medium composition from glucose concentration measurements
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    Chapter 33 Design of a bubble-swarm bioreactor for animal cell culture
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    Chapter 34 Cells and bubbles in sparged bioreactors
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    Chapter 35 Quantitative investigations of cell-bubble interactions using a foam fractionation technique
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    Chapter 36 Prediction of mechanical damage to animal cells in turbulence
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    Chapter 37 Repeated-batch cultures of Baby Hamster Kidney cell aggregates in stirred vessels
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    Chapter 38 Towards the development of a bioartificial pancreas: immunoisolation and NMR monitoring of mouse insulinomas
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    Chapter 39 Overview of a quality assurance/quality control compliance program consistent with FDA regulations and policies for somatic cell and gene therapies: a four year experience