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Dose Finding in Drug Development

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Cover of 'Dose Finding in Drug Development'

Table of Contents

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    Book Overview
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    Chapter 1 Introduction and New Drug Development Process
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    Chapter 2 Dose Finding Based on Preclinical Studies
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    Chapter 3 Dose-Finding Studies in Phase I and Estimation of Maximally Tolerated Dose
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    Chapter 4 Dose-Finding in Oncology—Nonparametric Methods
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    Chapter 5 Dose Finding in Oncology—Parametric Methods
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    Chapter 6 Dose Finding in Drug Development
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    Chapter 7 General Considerations in Dose–Response Study Designs
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    Chapter 8 Clinical Trial Simulation—A Case Study Incorporating Efficacy and Tolerability Dose Response
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    Chapter 9 Analysis of Dose–Response Studies—Emax Model
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    Chapter 10 Analysis of Dose–Response Studies—Modeling Approaches
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    Chapter 11 Multiple Comparison Procedures in Dose Response Studies
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    Chapter 12 Partitioning Tests in Dose–Response Studies with Binary Outcomes
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    Chapter 13 Analysis of Dose–Response Relationship Based on Categorical Outcomes
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    Chapter 14 Power and Sample Size for Dose Response Studies
Attention for Chapter 8: Clinical Trial Simulation—A Case Study Incorporating Efficacy and Tolerability Dose Response
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