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Chemical Carcinogenesis

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Cover of 'Chemical Carcinogenesis'

Table of Contents

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    Book Overview
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    Chapter 1 Cytochrome P-450 Function Analyses with Monoclonal Antibodies and cDNA Expression Vectors
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    Chapter 2 Cytochromes P-450 as Determinants of Susceptibility to Carcinogenesis by Aromatic Amines and Nitroaromatic Hydrocarbons
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    Chapter 3 Species-Dependent Differences in the Metabolic Activation of Polycyclic Aromatic Hydrocarbons in Cells in Culture
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    Chapter 4 Complex Metabolic Activation Pathways of Polycyclic Aromatic Hydrocarbons: 3-Hydroxy-trans-7,8-Dihydroxy-7,8-Dihydrobenzo[a]Pyrene as a Proximate Mutagen of 3-Hydroxybenzo[a]Pyrene
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    Chapter 5 Carcinogenicity of Methyl Halides: Current Problems Concerning Chloromethane
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    Chapter 6 Relationship Between Structure and Mutagenic/Carcinogenic Activity of Short Chain Aliphatic Halocompounds: A Collaborative Project
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    Chapter 7 Enzymatic Detoxication of Tumorigenic Bay-Region Diol-Epoxides of Polycyclic Aromatic Hydrocarbons by Conjugation with Glutathione
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    Chapter 8 Antigenotoxic and Anticarcinogenic Effects of Thiols. In Vitro Inhibition of the Mutagenicity of Drug Nitrosation Products and Protection of Rat Liver ADP-Ribosyl Transferase Activity
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    Chapter 9 Relationships between NADPH Content and Benzo(a)pyrene Metabolism in Normal and Glucose-6-Phosphate Dehydrogenase-Deficient Human Fibroblasts
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    Chapter 10 Comparison of the Covalent Binding of Various Chloroethanes with Nucleic Acids
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    Chapter 11 In Situ Detection of Hepatic AF-DNA Adduct Formation During Continuous Feeding of 0.02% Acetylaminofluorene and in Enzyme-Altered Foci Induced by Foyr Different Protocols
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    Chapter 12 Interaction of Activated N-Nitrosamines with DNA
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    Chapter 13 Antibodies Specific for DNA Components Modified by Chemical Carcinogens and Their Binding Efficiency to DNA Modified in Vivo and in Vitro with the Corresponding Carcinogens
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    Chapter 14 Liver DNA Damage by Chemical Carcinogens: Role of Thyroid Hormones
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    Chapter 15 Activation of Urinary Bladder Carcinogens within the Target Organ
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    Chapter 16 Lipid Peroxidation and Bioactivation of Halogenated Hydrocarbons in Rat Liver Mitochondria During Experimental Siderosis
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    Chapter 17 Lipid Peroxidation, Protein Thiols, Calcium Homeostasis and Imbalance of Antioxidant Systems in Bromobenzene Induced Liver Damage
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    Chapter 18 Cell Proliferation and Cell Loss in Progression in Liver Carcinogenesis: A New Hypothesis
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    Chapter 19 Human Papillomavirus 16 DNA and Epithelial Cell Immortalization
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    Chapter 20 Cellular and Molecular Studies of Growth, Differentiation and Neoplastic Transformation of Human Bronchial Epithelial Cells in Vitro
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    Chapter 21 New Insights into Tumor Promotion from Molecular Studies of Protein Kinase C
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    Chapter 22 Model Studies on the in Vitro Activation of c-Ha-ras Protooncogene by Dietary Components
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    Chapter 23 DNA Fragmentation or Changes in Chromatin Conformation. Results with Two Model Systems: Promotion in Rat Liver Carcinogenesis and Proliferation in Mastocytes
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    Chapter 24 Cellular and Molecular Changes in Early Stages of Hepatocarcinogenesis
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    Chapter 25 Sequential Phenotypic Conversion of Renal Epithelial Cells During Neoplastic Development
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    Chapter 26 The Wound Response as a Key Element for an Understanding of Multistage Carcinogenesis in Skin
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    Chapter 27 Possible Mechanism of Orotic Acid Induced Liver Tumor Promotion in the Rat
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    Chapter 28 The Role of Initiating and Promoting Properties in Aromatic Amine Carcinogenesis
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    Chapter 29 Long-Term Fate of the Hepatocyte Hyperplastic Foci Induced by a Two Stage Carcinogenetic Protocol
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    Chapter 30 Effects of Chronic Thioacetamide Administration on Liver Drug Metabolizing System and on the Development of Hepatocyte Foci, Nodules and Tumors
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    Chapter 31 Cell Death by Apoptosis in Normal, Preneoplastic and Neoplastic Tissue
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    Chapter 32 Role of Cell Death for Growth and Regression of Hormone-Dependent H-301 Hamster Kidney Tumors
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    Chapter 33 Can Apoptosis Influence Initiation of Chemical Hepatocarcinogenesis?
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    Chapter 34 Analysis of the Biology of Initiation Using the Resistant Hepatocyte Model
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    Chapter 35 Theoretical Calculations of the Electrostatic Potential of Some Tumor Promoters
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    Chapter 36 A Cell Culture Model for Study of Chemically-Derived and Spontaneous Mouse Lung Alveologenic Carcinoma
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    Chapter 37 Studies on Metabolic Perturbations and Tumor Promotion: Glycine Induces the Synthesis of Orotic Acid, a Tumor Promoter and the Expression of Certain Cell Cycle Dependent Genes
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    Chapter 38 Comparative Study on the Effect of Different Treatment Schedules on Some Carbohydrate Metabolizing Enzyme Activities in Rats During Hepatocarcinogenesis
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    Chapter 39 Expression of a Novel N-Acetylglucosaminyltransferase in Rat Hepatic Nodules
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    Chapter 40 Cytosolic and Plasmamembranes Enzymatic Activities During Diethylnitrosamine-Induced Carcinogenesis in Rat Liver
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    Chapter 41 Chemoprevention of Experimental Tumorigenesis by Dehydroepiandrosterone and Structural Analogs
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    Chapter 42 Inhibition of Initiation and Promotion Steps of Carcinogenesis by Glucose-6-Phosphate Dehydrogenase Deficiency
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    Chapter 43 Additive Effect of Low-Dose Diethylnitrosamine on the Initiation of Liver Carcinogenesis in Rats
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    Chapter 44 Modulation of Liver Carcinogenesis by Surgery
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    Chapter 45 Analysis of the Effects of Modifying Agents on Six Different Phenotypes in Preneoplastic Foci in the Liver in Medium-Term Bioassay Model in Rats
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    Chapter 46 S-Adenosylmethionine Antipromotion and Antiprogression Effect in Hepatocarcinogenesis. Its Association with Inhibition of DNA Methylation and Gene Expression
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    Chapter 47 Development and Application of an in Vivo Medium-Term Bioassay System for the Screening of Hepatocarcinogens and Inhibiting Agents of Hepatocarcinogenesis
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    Chapter 48 Nuclear Alterations in Liver Carcinogenesis: The Role of Non-Polyploidizing Growth
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    Chapter 49 Growth Control of Hepatocytes in Primary Culture and its Aberration in Carcinogenesis
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    Chapter 50 Constitutive and Induced Expression of Heat Shock Proteins During Liver Carcinogenesis and in Hepatomas
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    Chapter 51 Regulation of S-Adenosyl-L-Methionine Decarboxylase in Normal and Regenerating Rat Liver by Adenosine-Containing Molecules
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    Chapter 52 Derangements of Cationic Amino Acid Transport in Fibroblasts from Human Desmoid Tumor
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    Chapter 53 Lipids as Effectors and Mediators in Growth Control of Ascites Tumor Cells
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    Chapter 54 Susceptibility of grc-Bearing Rats to DEN and Its Relationship to the HMP Pathway
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    Chapter 55 Lipoproteins, Cell Proliferation and Cancer
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    Chapter 56 A Mechanistic Association Between Cholesterol Metabolism and Cell Proliferation
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    Chapter 57 Modifying Influence of Fasting on DNA Synthesis, Cholesterol Metabolism and HMP Shunt Enzymes in Liver Hyperplasia Induced by Lead Nitrate
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    Chapter 58 Regulation of Protein Degradation in Neoplastic Cells
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    Chapter 59 Proteolysis Associated with Thymidine-Induced Selective Cell Death in L-Cell Cultures
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    Chapter 60 Role of Intermediate Filaments and Ubiquitin in Protein Catabolism in Tumor Cells
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    Chapter 61 The Choline-Devoid Diet Model of Hepatocarcinogenesis in the Rat
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    Chapter 62 Methyl Insufficiency in Carcinogenesis
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    Chapter 63 Choline Deficiency, Lipid Peroxidation, Liver Cell Surface Receptor Alterations and Liver Tumor Promotion
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    Chapter 64 Mechanism of Initiation of Liver Carcinogenesis by Dietary Imbalance
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    Chapter 65 Modulation by Polyunsaturated Lipid Diets of Nitrosamine-Induced Cancers in Rats: Effects on Prooxidant State and Drug Metabolism
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    Chapter 66 Lipids and Colonic Carcinogenesis: Fact or Artefact?
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    Chapter 67 Mechanisms of Endogenous Nitrosation
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    Chapter 68 The Role of N-Nitroso Compounds in Human Cancer
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    Chapter 69 Models for Combined Action of Alcohol and Tobacco on Risk of Cancer: What Do We Really Know from Epidemiological Studies?
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    Chapter 70 Epidemiological Approach to the Investigation of Mechanisms of Action in Human Bladder Carcinogenesis
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    Chapter 71 Concluding Remarks
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Title
Chemical Carcinogenesis
Published by
Springer US, November 2013
DOI 10.1007/978-1-4757-9640-7
ISBNs
978-1-4757-9642-1, 978-1-4757-9640-7
Editors

Feo, Francesco, Pani, Paolo, Columbano, Amedeo, Garcea, Renato

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