↓ Skip to main content

Chemistry and Biology of Pteridines and Folates

Overview of attention for book
Cover of 'Chemistry and Biology of Pteridines and Folates'

Table of Contents

  1. Altmetric Badge
    Book Overview
  2. Altmetric Badge
    Chapter 1 Making Methionine: A Love Affair with Folate
  3. Altmetric Badge
    Chapter 2 Structure Elucidations of Dimeric Pteridines
  4. Altmetric Badge
    Chapter 3 A Selective Procedure for 6-Subsituted Pterin Derivatives: Synthesis and Substitution of Pterin 6-Triflate
  5. Altmetric Badge
    Chapter 4 Solution and Solid Phase Synthesis of Pteridines, Purines and Related Compounds
  6. Altmetric Badge
    Chapter 5 Synthesis of Pteridines With C-2 And C-6 Functional Group Diversity
  7. Altmetric Badge
    Chapter 6 Stereospecific Synthesis of 2-Desamino-Tetrahydropterins as Probes of Hydroxylase Cofactor Recognition
  8. Altmetric Badge
    Chapter 7 New Pyranopterin Chemistry Related to Molybdenum and Tungsten Enzymes
  9. Altmetric Badge
    Chapter 8 Application of FDCD Spectroscopy for Determination of Chiralities of Biologically Important Pteridines
  10. Altmetric Badge
    Chapter 9 Photo-Oxidation of Sepiapterin Produces Pterin-6-Carboxylic Acid and H 2 O 2 in Vitro
  11. Altmetric Badge
    Chapter 10 Regulation of Tyrosine Hydroxylase by S-Glutatiolation: Relevance to Conditions Associated with Dopamine Neuronal Damage
  12. Altmetric Badge
    Chapter 11 The Conformation of Tetrahydro-Biopterin Free and Bound to Aromatic Amino Acid Hydroxylases and NOS
  13. Altmetric Badge
    Chapter 12 Regulatory Properties of the Tetrahydropterin Cofactor in the Reaction Catalysed by Human Tyrosine Hydroxylase Isoforms 1–4
  14. Altmetric Badge
    Chapter 13 Structure and Regulation of Phenylalanine Hydroxylase, and Implications for Related Enzymes
  15. Altmetric Badge
    Chapter 14 Interaction of Phosphorylated Tyrosine Hydroxylase with 14-3-3 Proteins: Effects on Phosphorylation Kinetics
  16. Altmetric Badge
    Chapter 15 Mechanistic Studies of Tryptophan Hydroxylase
  17. Altmetric Badge
    Chapter 16 Role of PHE313/TRP326 in Determining Substrate Specificity in Tryptophan and Phenylalanine Hydroxylases
  18. Altmetric Badge
    Chapter 17 Possible Contributions of Labile Asparagine Residues to Differences in Regulatory Properties of Human and Rat Phenylalanine Hydroxylase
  19. Altmetric Badge
    Chapter 18 3-(2-Thienyl)-L-Alanine as a Competitive Substrate Analogue and Activator of Human Phenylalanine Hydroxylase
  20. Altmetric Badge
    Chapter 19 The N-Terminus of Human Tyrosine Hydroxylase is Responsible for its Association with Phospholipid Bilayers
  21. Altmetric Badge
    Chapter 20 Mechanisms of Tyrosine Hydroxylase Activation by Stress Activated Protein Kinases
  22. Altmetric Badge
    Chapter 21 Substrate Specificities of Phenylalanine and Tyrosine Hydroxylase: Role of Aspartate 425 of Tyrosine Hydroxylase
  23. Altmetric Badge
    Chapter 22 Mutation of W457 Alters N-Hydroxy-L-Arginine Oxidation by Inducible no Synthase: A Single Turnover Study
  24. Altmetric Badge
    Chapter 23 Regulation of Rat Hepatic Phenylalanine Hydroxylating System In Vivo
  25. Altmetric Badge
    Chapter 24 Estradiol Modulates GTP Cyclohydrolase I Gene Expression in Brain Catecholaminergic Systems
  26. Altmetric Badge
    Chapter 25 PKC-mediated Regulation of GTP Cyclohydrolase I in Mast Cells and Renal Mesangial Cells
  27. Altmetric Badge
    Chapter 26 Regulation of GTP Cyclohydrolase I by Estrogen
  28. Altmetric Badge
    Chapter 27 Sexually Dimorphic GTP Cyclohydrolase I Gene Expression is Independent of Sex Hormones
  29. Altmetric Badge
    Chapter 28 Studies on the Reaction Mechanism of GTP Cyclohydrolase I
  30. Altmetric Badge
    Chapter 29 Site-Directed Mutagenesis of Residues in the Active Site of Sepiapterin Reductase
  31. Altmetric Badge
    Chapter 30 Determination of Residues of Sepiapterin Reductase Phosphorylated by Ca 2+ /Calmodulin-Dependent Protein Kinase II
  32. Altmetric Badge
    Chapter 31 The Interaction of GTP Cyclohydrolase I and GTP Cyclohydrolase Feedback Regulatory Protein Can be Detected using the Yeast Two-Hybrid System
  33. Altmetric Badge
    Chapter 32 Co-Induction of Tetrahydrobiopterin and Catecholamine Syntheses in V-l-OVerexpressing PC12D Cells
  34. Altmetric Badge
    Chapter 33 Sepiapterin Administration Raises Tissue BH 4 Levels More Efficiently Than BH 4 Supplement in Normal Mice
  35. Altmetric Badge
    Chapter 34 Cells Take up BH4, Oxidize It and the Oxidized Biopterin is Preferentially Released
  36. Altmetric Badge
    Chapter 35 Catecholamines-up, a Negative Regulator of Tyrosine Hydroxylase and GTP Cyclohydrolase I in Drosophila Melanogaster
  37. Altmetric Badge
    Chapter 36 The Pteridine Pathway in the Zebrafish, Danio Rerio : Development in Neural Crest-Derived Cells and Its Control by GTP Cyclohydrolase I
  38. Altmetric Badge
    Chapter 37 Pteridine and Nitric Oxide Biosynthesis in Physarum Polycephalum
  39. Altmetric Badge
    Chapter 38 Pteridines and Pigment Granules of Wing Scales Concerned with Sexual Difference in Wing's Capability Reflecting Near-UV Rays in the Japanese Cabbage Butterfly Pieris Rapae Crucibora
  40. Altmetric Badge
    Chapter 39 Tetrahydrobiopterin, Nitric Oxide Synthesis and cGMP Concentrations in Mutants of Physarum Polycephalum with Altered Sporulation Behavior
  41. Altmetric Badge
    Chapter 40 BH 4 and NOS are Involved in LightControlled Development of Sporangiophores in the Fungus Phycomyces Blakesleeanus
  42. Altmetric Badge
    Chapter 41 Determination of Tetrahydropterins as Native Pteridines in Two Microorganisms, Tetrahymena Pyriformis and E. Coli
  43. Altmetric Badge
    Chapter 42 Identification of the Sulfurtransfer Pathway for the Generation of the Dithiolene Moiety of Molybdopterin in Escherichia Coli
  44. Altmetric Badge
    Chapter 43 Tetrahydrobiopterin and Vascular Endothelial Function
  45. Altmetric Badge
    Chapter 44 L-Ascorbic Acid Increases Intracellular Tetrahydrobiopterin Via A Chemical Stabilization and Potentiates Nitric Oxide Synthesis in Endothelial Cells
  46. Altmetric Badge
    Chapter 45 The Redox Status of Bound Pterin Cofactor Determines Whether eNOS Produces NO or Superoxide Anion: [ 3 H]-BH 4 Binding Studies Provide Insights into Vascular Pathophysiology
  47. Altmetric Badge
    Chapter 46 Sepiapterin Reductase Deficiency: Molecular Analysis in a New Case Presenting with Neurotransmitter Deficiency without Hyperphenylalaninemia
  48. Altmetric Badge
    Chapter 47 Molecular Basis of DOPA-Responsive Dystonia
  49. Altmetric Badge
    Chapter 48 Human Nigrostriatal Dopamine Neurons Express Low Levels of GTP Cyclohydrolase I mRNA
  50. Altmetric Badge
    Chapter 49 Immunosuppressive Effects of the 4-Amino Analogue of Tetrahydrobiopterin
  51. Altmetric Badge
    Chapter 50 Tetrahydrobiopterin Responsive Hyperphenylalaninemia without Biopterin Deficiency
  52. Altmetric Badge
    Chapter 51 The Fate of Intravenously Administered Tetrahydrobiopterin and Its Implications for Heterologous Gene Therapy of Phenylketonuria
  53. Altmetric Badge
    Chapter 52 Influence of Hydrogen Peroxide (H 2 O 2 ) on Pterin Homeostasis in the Depigmentation Disorder Vitiligo
  54. Altmetric Badge
    Chapter 53 Catechol-O-Methyltransferase Inhibition in the Treatment of Tetrahydrobiopterin Deficiency
  55. Altmetric Badge
    Chapter 54 Changes in Dihydropteridine Reductase (DHPR) Activity of the Occupationally Lead Exposed Workers
  56. Altmetric Badge
    Chapter 55 Clinical Utility of Pteridine Measurement in Cerebrospinal Fluid
  57. Altmetric Badge
    Chapter 56 Effect of Ascorbic Acid in Measurement of Serum Pteridine Concentration
  58. Altmetric Badge
    Chapter 57 The Effect of Tetrahydrobiopterin (BH 4 ) on Sperm Motility
  59. Altmetric Badge
    Chapter 58 Tetrahydrobiopterin Deficiency in Diabetic Rats
  60. Altmetric Badge
    Chapter 59 The Effect of Tetrahydrobiopterin (BH 4 ) on Diabetic Nephropathy in Streptozotocin (STZ) Induced Diabetic Rats
  61. Altmetric Badge
    Chapter 60 Determination of Sepiapterin and Sepiapterin Reductase in Human Skin
  62. Altmetric Badge
    Chapter 61 Neopterin, an Immunodiagnostic and Oxidative Stress Indicator
  63. Altmetric Badge
    Chapter 62 Role of Neopterin in Immune Monitoring in Transplant Medicine
  64. Altmetric Badge
    Chapter 63 Neopterin and 7,8-Dihydroneopterin-Induced Signal Transduction Cascades in Cell Lines
  65. Altmetric Badge
    Chapter 64 Determination of Neopterin Levels in Gingival Crevicular Fluid (GCF)
  66. Altmetric Badge
    Chapter 65 Neopterin and Biopterin Levels in Pregnancy
  67. Altmetric Badge
    Chapter 66 Tetrahydrobiopterin (BH 4 )-Mediated Neuronal Death Following Intrastriatal Kainic Acid: Implications for Parkinson’s Disease
  68. Altmetric Badge
    Chapter 67 Inhibition of Oxidative Stress during Developmental Cell Death: Cellular and Behavioral Effects
  69. Altmetric Badge
    Chapter 68 The Role of Tetrahydrobiopterin (BH 4 ) in Trophic Factor Withdrawal-Induced Apoptosis in PC12 Cells
  70. Altmetric Badge
    Chapter 69 Apoptotic Death of PC12 cells Induced by Ischemia-Like Conditions is Mediated by Tetrahydrobiopterin (BH 4 ) Metabolism
  71. Altmetric Badge
    Chapter 70 New Approaches Towards Inhibitors of Folate-Dependent Enzymes: Rapid Synthesis of 5-Deazapterins From Uracil Derivatives
  72. Altmetric Badge
    Chapter 71 Solid and Solution Phase Strategies for the Synthesis of Potential Inhibitors of Folate Biosynthesis
  73. Altmetric Badge
    Chapter 72 Progress Towards the Synthesis of Pyrimidodiazepine-Based Folates as Potential Inhibitors of Glycinamide Ribonucleotide Formyltransferase
  74. Altmetric Badge
    Chapter 73 Role of P53 Status on Sensitivity to Thymidylate Synthase Inhibitors and Induction of Apoptosis
  75. Altmetric Badge
    Chapter 74 Synthesis of N-[4-[(2-Amino-6-Methyl-3,4-Dihydro-4-Oxo-7 H -Pyrrolo[2,3- d ]-Pyrimidin-5-Yl)Methyl]Benzoyl]- L -Glutamic Acid as an Antifolate
  76. Altmetric Badge
    Chapter 75 Effect of Bridge Truncation of Classical 2,4-Diamino-5-Substituted Furo [2,3- d ] Pyrimidine and 2-Amino-4-Oxo-6-Substituted Pyrrolo [2,3- d ] Pyrimidine on Antifolate Activity
  77. Altmetric Badge
    Chapter 76 Selection of Methotrexate-Resistant Lactobacillus Casei in the Presence of Folate or 5-Formyl-Tetrahydrofolate Affects the Resistance Mechanism
  78. Altmetric Badge
    Chapter 77 Molecular Mechanisms of Resistance to Antimalarial Antifolate Drug Pyrimethamine-Sulfadoxine
  79. Altmetric Badge
    Chapter 78 5-Fluorouracil Induction of Fas and Apoptosis in Colon Cancer Patients: Relation of Clinical Outcome with Thymidylate Synthase, Mcl-1 and Rb
  80. Altmetric Badge
    Chapter 79 Synthesis of 2- or 4-Seleno Analogues of dUMP and FdUMP, and the Corresponding Nucleosides. Interactions with Mammalian Tumour Thymidylate Synthase of the Selenonucleotides and Inhibition of Tumor Cell Growth by the Selenonucleosides
  81. Altmetric Badge
    Chapter 80 Induction of Resistance to the Multi-Targeted Antifolate MTA (LY231514) in Widr Human Colon Cancer Cells
  82. Altmetric Badge
    Chapter 81 Mutational Studies of an Essential Glutamate Residue in Escherichia Coli Folylpolyglutamate Synthetase with a Role in ATP Binding
  83. Altmetric Badge
    Chapter 82 Rapid Purification of the T-Protein of the Glycine Cleavage System from Rabbit Liver
  84. Altmetric Badge
    Chapter 83 Effects of Cellular Glycine on Cell Proliferation
  85. Altmetric Badge
    Chapter 84 Microarray Analysis of Genes Induced by Methionine Starvation and Growth on Different Sulfur Sources in Yeast
  86. Altmetric Badge
    Chapter 85 Gene Structure and Expression of Trichinella Spiralis Thymidylate Synthase
  87. Altmetric Badge
    Chapter 86 Lack of Mutation of L1210 Thymidylate Synthase with Altered Sensitivity to FdUMP Inhibition
  88. Altmetric Badge
    Chapter 87 Enzymes of Thymidylate Biosynthesis in Trichinella Pseudospiralis Muscle Larvae and Caenorhabditis Elegans Dauer Larvae
  89. Altmetric Badge
    Chapter 88 Thymidylate Synthase Heterogeneity Assessed by Monoclonal Antibodies
  90. Altmetric Badge
    Chapter 89 Structure-Based Modeling of Reversed N9-C10 Bridge Antifols with Human, PC and TG DHFR
  91. Altmetric Badge
    Chapter 90 Regulation of Mammalian Methionine Synthase by B 12
  92. Altmetric Badge
    Chapter 91 Biochemical Studies of Human Methionine Synthase Reductase
  93. Altmetric Badge
    Chapter 92 Model Studies for the B 12 Dependent Methyltransferases
  94. Altmetric Badge
    Chapter 93 Betaine-Homocysteine S-Methyl-Transferase (BHMT) Transcription is Inhibited by S-Adenosylmethionine (AdoMet)
  95. Altmetric Badge
    Chapter 94 Can Elevated Plasma Homocysteine Levels Result in the Inhibition of Intracellular Methyltransferases?
  96. Altmetric Badge
    Chapter 95 The Neuropathy of Disturbed Brain Methylation Reactions
  97. Altmetric Badge
    Chapter 96 Dopamine-Stimulated Solid-State Signaling: A Novel Role for Single-Carbon Folates in Human Attention
  98. Altmetric Badge
    Chapter 97 Is Moderate Hyperhomocysteinemia Due to Folic Acid Depletion Rather than Insufficient Dietary Intake?
  99. Altmetric Badge
    Chapter 98 C677T MTHFR Genotype is a Risk Factor for Thromboembolism: Comparison of T Allele Frequency and Homocysteine Level Between Female Thromboembolic and Non-Thromboembolic Vascular Patients, NTD Mothers and Matched NTD Controls
  100. Altmetric Badge
    Chapter 99 Molecular Bases of Hyper-Homocysteinemia due to Inborn Errors of Folate and Cobalamin Metabolism
  101. Altmetric Badge
    Chapter 100 Vitamin B6 (PLP) and Neural Tube Defects: Is There an Association?
  102. Altmetric Badge
    Chapter 101 Erythrocyte Folate Levels in Operating Room Personnel
  103. Altmetric Badge
    Chapter 102 A Human Ileostomy Model to Determine Folate Bioavailability from Food
  104. Altmetric Badge
    Chapter 103 12 Channel Coulometric Electrochemical Detection for the Identification of Polyglutamate Homology Amongst Cellular Folates
  105. Altmetric Badge
    Chapter 104 Gastro-Intestinal pH Modulates Facile Interconvertion of Native Formylfolates During Absorption
  106. Altmetric Badge
    Chapter 105 Control of Folate Production in Lactic Acid Bacteria by Using Metabolic Engineering
  107. Altmetric Badge
    Chapter 106 Evidence for a Cryptic Gene that Enables E. Coli to Specifically Transport Folate Analogs
  108. Altmetric Badge
    Chapter 107 Folate Transport Abnormalities and Congenital Defects
  109. Altmetric Badge
    Chapter 108 Role of Multidrug Resistance Proteins (MRP) in Resistance to Antifolates and Folate Homeostasis
  110. Altmetric Badge
    Chapter 109 Kinetics of Reduced Folate Carrier-and Membrane-Associated Folate Receptor-Mediated Transport of Antifolates
  111. Altmetric Badge
    Chapter 110 Cell Biology and Regulation of the Intestinal Folate Absorption Process
Overall attention for this book and its chapters
Altmetric Badge

Mentioned by

wikipedia
1 Wikipedia page

Citations

dimensions_citation
24 Dimensions

Readers on

mendeley
4 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Chemistry and Biology of Pteridines and Folates
Published by
Springer US, December 2012
DOI 10.1007/978-1-4615-0945-5
ISBNs
978-1-4613-5317-1, 978-1-4615-0945-5
Editors

Milstien, Sheldon, Kapatos, Gregory, Levine, Robert A., Shane, Barry

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 4 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 4 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 1 25%
Unknown 3 75%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 1 25%
Unknown 3 75%