Chapter 1 The chemistry and cellular biology of the tetracyclines

Chapter 2 Proton and metal ion binding of tetracyclines

Chapter 3 Gene regulation by the tetracycline-inducible Tet repressor-operator system — molecular mechanisms at atomic resolution

Chapter 4 Regulation of gene expression in yeast and plants by tetracycline-dependent regulatory systems

Chapter 5 Tetracyclines in the control of gene expression in eukaryotes

Chapter 6 Tetracycline-regulated gene expression to study oncogenes in vivo

Chapter 7 Interactions of tetracyclines with RNA

Chapter 8 Biological, non-antibiotic properties of semi-synthetic and chemically modified tetracyclines — a structured, annotated bibliography

Chapter 9 Tetracycline consumption in prehistory

Chapter 10 Tetracycline treatment of periodontal disease: antimicrobial and non-antimicrobial mechanisms

Chapter 11 Inhibition of matrix metalloproteinases (MMPs) by tetracyclines

Chapter 12 Structure/function studies of doxycycline effects on matrix metalloproteinase activity and cartilage degeneration

Chapter 13 Regulation of inflammatory mediators by tetracyclines

Chapter 14 Tetracyclines and autoimmunity