Chapter 1 Tumor Physiology and Resistance to Chemotherapy: Repopulation and Drug Penetration

Chapter 2 The role of membrane transporters in cellular resistance to anticancer nucleoside drugs.

Chapter 3 MDR and MRP gene families as cellular determinant factors for resistance to clinical anticancer agents.

Chapter 4 The Glutathione System in Alkylator Resistance

Chapter 5 The Role of Signal Transduction Pathways in Drug and Radiation Resistance

Chapter 6 Mechanisms of repair of interstrand crosslinks in DNA.

Chapter 7 DNA Repair in Resistance to Bifunctional Alkylating and Platinating Agents

Chapter 8 Leukemic Cell Insensitivity to Cyclophosphamide and other Oxazaphosphorines Mediated by Aldehyde Dehydrogenase(s)

Chapter 9 Mechanisms of Resistance against Cyclophosphamide and Ifosfamide: Can they be Overcome without Sacrificing Selectivity?

Chapter 10 Cellular mechanisms of cyclophosphamide resistance: model studies in human medulloblastoma cell lines.

Chapter 11 Model studies of cyclophosphamide resistance in human myeloid leukemia.

Chapter 12 Mechanisms of drug resistance in AML.

Chapter 13 Biochemical and molecular mechanisms of cisplatin resistance.

Chapter 14 Modification of Radiosensitivity Following Chemotherapy Exposure: Potential Implications for Combined-Modality Therapy

Chapter 15 Clinical pharmacology of melphalan and its implications for clinical resistance to anticancer agents.

Chapter 16 Pharmacological Considerations of Primary Alkylators

Chapter 17 Genomic Approaches to Clinical Drug Resistance