Chapter title |
Nonselective Cation Channels and Links to Hippocampal Ischemia, Aging, and Dementia
|
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Chapter number | 37 |
Book title |
Sodium Calcium Exchange: A Growing Spectrum of Pathophysiological Implications
|
Published in |
Advances in experimental medicine and biology, January 2013
|
DOI | 10.1007/978-1-4614-4756-6_37 |
Pubmed ID | |
Book ISBNs |
978-1-4614-4755-9, 978-1-4614-4756-6
|
Authors |
John F. MacDonald, Jillian C. Belrose, Yu-Feng Xie, Michael F. Jackson, MacDonald, John F., Belrose, Jillian C., Xie, Yu-Feng, Jackson, Michael F. |
Abstract |
Stroke is a very strong risk factor for dementia. Furthermore, ischemic stroke and Alzheimer's disease (AD) share a number of overlapping mechanisms of neuron loss and dysfunction, including those induced by the inappropriate activation of N-methyl-D-aspartate receptors (NMDARs). These receptors form a major subtype of excitatory glutamate receptor. They are nonselective cation channels with appreciable Ca(2+) permeability, and their overactivation leads to neurotoxicity in the cortex and hippocampus. NMDARs have therefore been therapeutic targets in both conditions, but they have failed in the treatment of stroke, and there is limited rationale for using them in treating AD. In this chapter, we discuss current understanding of subtypes of NMDARs and their potential roles in -ischemic stroke and AD. We also discuss the properties of several other nonselective cation channels, transient receptor potential melastatin 2 and 7 channels, and their implications in linking these conditions. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 16 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 3 | 19% |
Student > Bachelor | 2 | 13% |
Student > Ph. D. Student | 2 | 13% |
Student > Master | 2 | 13% |
Researcher | 2 | 13% |
Other | 1 | 6% |
Unknown | 4 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 38% |
Neuroscience | 3 | 19% |
Psychology | 1 | 6% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 6% |
Chemistry | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 25% |