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Further Studies in the Assessment of Toxic Actions

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Cover of 'Further Studies in the Assessment of Toxic Actions'

Table of Contents

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    Book Overview
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    Chapter 1 Assessment of Mutagenicity Tests
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    Chapter 2 Testing of Medicines for Their Mutagenic Potency. Proposition from a French Working Party
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    Chapter 3 Monitoring the Occupational Exposure to Mutagens by the Cytogenetic Analysis of Human Peripheral Lymphocytes in vivo
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    Chapter 4 Elevated Mitotic Number in the Adrenal Cortex as a Reflection of Early Events in Growth Induction by Carcinogens and Promoters — A Possible Short-Term Assay
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    Chapter 5 Sister Chromatid Exchanges in Chinese Hamster Embryonic Liver Cells Exposed Transplacentally to Bromodeoxyuridine (BrdU) and Chemical Mutagens
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    Chapter 6 Differences in Carcinogenicity After Transplacental and Postnatal Administration of Drugs and Pesticides
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    Chapter 7 Combination Effects in Chemical Carcinogenesis
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    Chapter 8 Chromosome Aberration Tests with Chinese Hamster Cells in vitro with and without Metabolic Activation — A Comparative Study on Mutagens and Carcinogens
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    Chapter 9 Ligand Binding of Safrole to Cytochrome P-450
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    Chapter 10 Testing of Drugs for Combined Mutagenesis with Sodium Nitrite in the Host-mediated Assay
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    Chapter 11 Biotransformation and Spectral Interaction of Xenobiotics with Subcellular Fractions from Drosophila Melanogaster
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    Chapter 12 Mutagenicity of DNOC in Drosophila Melanogaster
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    Chapter 13 Standardization of Clastogenicity and SCE Assays on Mammalian Cells in vitro — Results and Problems
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    Chapter 14 Influence of Experimental Factors on the Mutagenicity of Vinylic Monomers
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    Chapter 15 Modification of Mutagenic Activity of Anticancer Drugs
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    Chapter 16 Mutagenic Activity in Foundry Air
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    Chapter 17 The Effect of Carcinogens and Non-Carcinogens on Some Biochemical Features of the Mouse Lung Tissue
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    Chapter 18 Attempt to develop new mouse colony with high susceptibility to carcinogens.
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    Chapter 19 Metabolizing Activities of Postmitochondrial Liver Fractions (S-9) on Benzo[a]pyrene and Dimethylnitrosamine
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    Chapter 20 Reduced Induction of Pyruvate Kinase After Feeding 2-Acetylaminofluorene
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    Chapter 21 Chemical Carcinogens: Screening, Testing, Risk Assessment for Man
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    Chapter 22 Studies on the Detection of Chemical Carcinogens Using a Mammalian Cell Transformation Assay. A Correlated Study of BHK Cell Transformation and Bacterial Mutagenicity
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    Chapter 23 Chronic and Carcinogenic Study of Trinitroglycerin in Rats, Mice and Dogs
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    Chapter 24 Induction of Pituitary Tumours and Hyperprolactinemia in Female Rats by Estrogens. The Effect of Apomorphine, Reserpine and L-DOPA
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    Chapter 25 Immunotoxicity Assessment: Screening and Function Studies
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    Chapter 26 Immunopharmacology and its Toxicological Problems
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    Chapter 27 Some Approaches to Experimental Testing of Drugs for Immunotoxicity
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    Chapter 28 Pharmacokinetics and Immunotoxicity
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    Chapter 29 Effects of Toxicants on T-cell Subpopulations as Determined by Lymphokine Activity
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    Chapter 30 A Simple Technique of Testing for the Influence of Metal Salts and Other Chemicals on Macrophages and Thymocytes in vitro
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    Chapter 31 Toxicity of Organotin Compounds in Chicken and Rats
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    Chapter 32 Inhibition of Immune Response by Diisopropyl Phosphorofluoridate
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    Chapter 33 Thymocyte Stimulating Activity of the Serum of Rats in the Early Phase After 2-Acetylaminofluorene (AAF)-Treatment
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    Chapter 34 Lysozyme (Muramidase) and Hemolytic Complement (CH 50 U) in Sera of Beagle Dogs and Minipigs After Longterm Application of Different Preparations of Estrogens and Gestagens
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    Chapter 35 The Effect of Acute Administration of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) on Humoral Antibody Production and Cell-Mediated Activities in Mice
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    Chapter 36 Quantitative Development of Immunoglobulin (IgG) During Life-Span of Male and Female Laboratory Rat
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    Chapter 37 Studies on the Action of Dimethoate on the Immune System
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    Chapter 38 The Effect of DDVP, an Organophosphorus Pesticide on the Humoral and Cell-Mediated Immunity of Rabbits
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    Chapter 39 The Relationship Between the Length of the Alkyl Chain of Dialkyltin Compounds and their Effects on Thymus and Bile Ducts in Mice
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    Chapter 40 Allergic Encephalomyelitis in Rats — Toxicity Assay for Pertussis Vaccines
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    Chapter 41 Some Aspects of Testing Drugs for Nephrotoxicity in Rats
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    Chapter 42 Nephrotoxicity of Drugs, Evaluated by Renal Enzyme Excretion Studies
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    Chapter 43 Urinary Enzyme Excretion and Changes in Renal Functions Induced by Toxic Substances or by Renal Ischemia in Rats
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    Chapter 44 Stimulation of Kidney Function in Rats Injured by Nephrotoxic Agents
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    Chapter 45 Relationship Between Exposure to Heavy Metals and Prevalence of Renal Dysfunction
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    Chapter 46 Nephrotoxicity of the Flame Retardant Tris(2,3-Dibromopropyl)Phosphate
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    Chapter 47 Evaluation of Renal Dysfunction Induced by Cadmium in Man by Determination of Enzymes and Specific Proteins in Urine
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    Chapter 48 Testing of Drugs for Nephrotoxicity General Principles and Minimal Criteria
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    Chapter 49 Hydroxyurea as a Reference Standard in Teratological Screening
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    Chapter 50 Embryotoxic Effects of Post-Coital Fertility Inhibiting Steroids
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    Chapter 51 Subtle Consequences of Prenatal Exposure to Low Carbon Disulphide Levels
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    Chapter 52 Behaviour Teratology Tests
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    Chapter 53 Testing for Embryotoxicity
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    Chapter 54 Morphogenetic Systems and Screening for Embryotoxicity
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    Chapter 55 The State and Future Requirements of Teratogenic Testing
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    Chapter 56 Behavioural Tests in Peri- and Post-Natal Toxicity Study in Rats of Trithiozine (Tresanil)
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    Chapter 57 Influence of Thalidomide on Alkaline (AP) and Acid (ACP) Phosphatase Activities in Rat Fetuses and Mothers
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    Chapter 58 Experiences with a Three Step Test Scheme for Embryotoxicity and Teratogenicity
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    Chapter 59 Postnatal Effects of Oral Administration of Ethylenethiourea to Rats During Late Pregnancy
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    Chapter 60 Activity of Some Mixed Function Oxidases in Prenatally Carbon Disulphide (CS 2 ) Treated Rats
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    Chapter 61 Endocrine Aspects of Ozone Exposure in Rats
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    Chapter 62 Significance of Mode of Exposure in Aerosol Inhalation Toxicity Studies — Head only Versus Whole Body Exposure
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    Chapter 63 Pharmacokinetic Studies with 3 H-Cytisine
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    Chapter 64 Kinetics of Benzene Metabolism in Rats in Inhalation Exposure
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    Chapter 65 Estimation of Occupational Exposure to Phenoxy Acids (2,4-D and 2,4,5-T)
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    Chapter 66 Acrylonitrile Metabolism in the Rat
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    Chapter 67 Changes of Pharmacokinetics and Metabolism of Sulfadimidine in Endotoxin Pretreated Rabbits
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    Chapter 68 Effect of Hydrocortisone on Oxidative Degradation of Hexobarbital and Ethylmorphine
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    Chapter 69 Study of the Protective Effect of an Anabolic Steroid, 19-Nortestosterone Phenylpropionate (19-NTPP) on the Fatty Liver Induced by High Doses of Rifampicin in the Rat
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    Chapter 70 Comparative in vitro Investigations on the Dialysability of Hypnotic and Psychotropic Drugs by Hemodialysis and Controlled Sequential Ultradiffusion
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    Chapter 71 The Excretion of Ascorbic Acid and Hippuric Acid in the Urine of Rats with Liver Injury
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    Chapter 72 Evaluation of Liver Function Tests After Administration of Aminophenazone
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    Chapter 73 Effects of Some Cholephilic Agents on Hepatic Mitochondrial Respiration and Biliary Excretion
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    Chapter 74 The Fate of Propoxur in Rat
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    Chapter 75 Different Role of Biotransformation in the Elimination of Some Important Pharmaceuticals and Industrial Xenobiotics
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    Chapter 76 The Effect of Heavy Metals (Lead, Manganese, Mercury) on the Concentration of Free Amino Acids in the Liver of Rats
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    Chapter 77 Involvement of Phenolic Metabolites in the Irreversible Protein-Binding of 14 C-Bromobenzene Catalysed by Rat Liver Microsomes
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    Chapter 78 Effect of Acute Intoxication with Some Heavy Metals on Drug Metabolism
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    Chapter 79 Single intravenous dose kinetics accumulation of atenolol in patients with impaired renal function and on hemodialysis.
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    Chapter 80 Hepatic Nuclear Protein Kinases in Young Rats Pretreated with 3-Methylcholanthrene
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    Chapter 81 Hepatic Nuclear Free and Engaged RNA-Polymerases in Young Rats Pretreated with 3-Methylcholanthrene
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    Chapter 82 The Role of Metabolic Factors in the Interaction Between Opiates and Homopyrimidazoles in the Central Nervous System
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    Chapter 83 Research on Pharmacokinetics During Pregnancy
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    Chapter 84 Towards Standardization of the Reconstituted Mixed Function Oxidase Systems with Cytochrome P-450
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    Chapter 85 Excretion of Nalidixic Acid via Mother’s Milk
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    Chapter 86 Effect of Insulin on the Biliary Excretion of Some Organic Anions in Rats
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    Chapter 87 Aspects of Methodology Employed in the Investigation of Combined Chemical Effects on Acute Oral Toxicity
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    Chapter 88 Modification of Toxicity of Violamycin BI (VBI) by Complex Formation with DNA, Metal Ions, and by Pretreatment with α -Tocopherol
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    Chapter 89 Comparative Studies on Cardiotoxicity of Some Anthracycline Antitumor Antibiotics
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    Chapter 90 The Influence of Drugs on the Acute Toxicity of Cytisine
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    Chapter 91 Requirements for Toxicological Evaluation of New Pesticides in Poland and the GDR
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    Chapter 92 Therapy of Acute Oral Poisonings by Organic Solvents: Treatment by Activated Charcoal in Combination with Laxatives
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    Chapter 93 Toxicity Evaluation of Water Soluble Substances of Dental Materials by Means of Cell Population in vitro
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    Chapter 94 Cardiotoxicity of Drugs Detected on Chicken Embryos
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    Chapter 95 The effect of high concentrations of oxygen on paraquat and diquat toxicity in rats.
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    Chapter 96 Planning of Experiments for the Testing of Chronic Toxicity in Rats Taking into Account Biorhythms
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    Chapter 97 Acute and Cutaneous Toxicity of β -Chlorovinyl Ketones and Aldehydes in Rodents
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    Chapter 98 Cardiotoxicity from Orphenadrine Intoxications in Humans
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    Chapter 99 Morphological and Biochemical Criteria for Evaluating Cytotoxic Effects of Antiviral Substances
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    Chapter 100 Toxicological Effects of Steam-Sterilized High Lactose Diets on Conventional and Gnotobiotic Rats
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    Chapter 101 Effects on Mice of Numbers of Animals per Cage: An 18-Month Study (Preliminary Results)
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    Chapter 102 Toxicological Tests on the Safety of Fermosin for Pigs, a Novel Microbial Feed from Petroleum Distillate
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    Chapter 103 Nutritional Toxicological Studies with Lannate: Interactions with Caffeine and Ethanol
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    Chapter 104 The Occurrence of Carcinogenic Polycyclic Hydrocarbons in Foodstuffs in Hungary
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    Chapter 105 An Evaluation of the Toxicity of Thiuram in Combination with Other Pesticides
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    Chapter 106 Testicular atrophy produced by phthalate esters.
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    Chapter 107 Different Pituitary Prolactin Cell-Stimulating Effects of Various Estrogens in Female Rats
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    Chapter 108 Changes in the Gonads Reproduction and Generations of White Rats Under the Effect of Some Pesticides
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    Chapter 109 Clofibrate and the Development of Rats
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    Chapter 110 Drug-Induced Histological Changes in Rat Seminiferous Tubular Epithelium
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    Chapter 111 The Influence of Haloperidol Pretreatment on the Morphine Toxicity
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    Chapter 112 Neurochemical Alterations in Rat Brain as a Test for Studying the Neurotoxicity of Organophosphorus Insecticides
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    Chapter 113 Effects of Preceding Sensibilization by Reserpine and Haloperidol on Toxicity of Dopaminergic Agonists
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    Chapter 114 The Use of Radionuclides for Evaluation of Dermal Irritation with Drugs
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    Chapter 115 Influence of Gold Salts on the Content of Trace Elements in Serum of Patients with Rheumatoid Arthritis Under Sanocrysin Treatment
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    Chapter 116 The Influence of Acetylsalicylic Acid, Phenylbutazone, Indometacin, and Flufenamic Acid on the Kinetics of Leucocytes During Acute Inflammation
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    Chapter 117 Influence of Liver Enzyme Induction Caused by Diphenylhydantoin and Diazepam on Bone Mass of Rats
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Title
Further Studies in the Assessment of Toxic Actions
Published by
Springer Berlin Heidelberg, December 2012
DOI 10.1007/978-3-642-67729-8
ISBNs
978-3-54-010191-8, 978-3-64-267729-8
Editors

Chambers, Philip L., Klinger, Wolfgang

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