Chapter title |
Primary malignant lymphomas of the central nervous system in man.
|
---|---|
Chapter number | 16 |
Book title |
Malignant Lymphomas of the Nervous System
|
Published in |
Acta neuropathologica Supplementum, January 1975
|
DOI | 10.1007/978-3-662-08456-4_16 |
Pubmed ID | |
Book ISBNs |
978-3-54-007208-9, 978-3-66-208456-4
|
Authors |
K Jellinger, T H Radaskiewicz, F Slowik, Jellinger, K, Radaskiewicz, T H, Slowik, F, Jellinger, K., Radaskiewicz, Th., Slowik, F. |
Abstract |
Sixty-eight primary malignant lymphomas of the CNS exclusively confined to the brain and its leptomeninges from a series of about 8000 intracranial neoplasms (incidence 0.85%) were examined and classified according to current histopathologic criteria. Average age at onset of symptoms was 55 years, mean duration of illness to time of diagnosis was 3 months. Survival averaged 1,8 months with supportive care, but 17,2 months with surgery, radiation and/or chemotherapy. CSF cytology was useful and reliable tool for clinical diagnosis. The cerebral hemispheres were affected in about 50%, the basal ganglia in 18%, posterior fossa in 10%, while multifocal lesions amounted to 22%. All CNS tumors were of the diffuse type of non-Hodgkin's lymphomas; no follicular (germinal center) lymphomas were observed. Three histological patterns comparable to extraneural lymphomas were distinguished: Immunoblastoma (reticulosarcoma) occurred most frequently (58.8%), lympho-plasmacytoid immunocytoma constituted 28 percent, while lymphoblastic lymphoma occurred least frequently (13.2%). There were no significant differences with regard to onset, location, growth pattern or clinical course except for a much poorer prognosis of lymphoblastic lymphoma. Although there are no definite cytological differences between malignant lymphomas arising in extraneural sites or as primary lesions in the CNS, the latter showed a much greater proportion of phagocyting histiocytes (and microglia) and a frequent occurrence of plasmacytes and their precursors which apparently exceded pure host reaction. The prognostic value of modern classification schemes for CNS lymphomas needs further critical evaluation. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 3 | 20% |
Researcher | 3 | 20% |
Student > Ph. D. Student | 2 | 13% |
Other | 1 | 7% |
Professor > Associate Professor | 1 | 7% |
Other | 0 | 0% |
Unknown | 5 | 33% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 4 | 27% |
Neuroscience | 3 | 20% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Agricultural and Biological Sciences | 1 | 7% |
Unknown | 6 | 40% |