Chapter title |
Regulation of Cdc2 activity by phosphorylation at T14/Y15.
|
---|---|
Chapter number | 10 |
Book title |
Progress in Cell Cycle Research
|
Published in |
Progress in cell cycle research, January 1996
|
DOI | 10.1007/978-1-4615-5873-6_10 |
Pubmed ID | |
Book ISBNs |
978-1-4613-7693-4, 978-1-4615-5873-6
|
Authors |
Lynne D. Berry, Kathleen L. Gould, Berry, Lynne D., Gould, Kathleen L. |
Abstract |
The highly conserved Cdc2 serine/threonine kinase plays a central role in cell cycle progression. Although Cdc2 levels remain constant throughout the cell cycle, Cdc2 kinase activity peaks at the G2/M boundary, in order to drive entry into mitosis. In the model organism Schizosaccharomysces pombe, potentially active Cdc2/Cdc13 kinase complex accumulates throughout the S and G2 phases of the cell cycle. This complex, however, is maintained in an active state by Wee1/Mik1-mediated phosphorylation at Y15 (and, possibly, T14). At the G2/M boundary, the Cdc25 protein phosphatase is activated to dephosphorylate the Cdc2/Cdc13 complex, resulting in abrupt activation of Cdc2 kinase activity and entry into mitosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 9 | 35% |
Student > Bachelor | 4 | 15% |
Researcher | 3 | 12% |
Professor | 2 | 8% |
Lecturer > Senior Lecturer | 1 | 4% |
Other | 3 | 12% |
Unknown | 4 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 12 | 46% |
Biochemistry, Genetics and Molecular Biology | 4 | 15% |
Medicine and Dentistry | 2 | 8% |
Unspecified | 1 | 4% |
Business, Management and Accounting | 1 | 4% |
Other | 1 | 4% |
Unknown | 5 | 19% |