Proteasome Inhibitors in Cancer Therapy

Table of Contents

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   Book Overview
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   Chapter 1 Cancer Drug Development
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   Chapter 2 Introduction to the Proteasome and its Inhibitors
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   Chapter 3 Structures of the Yeast Proteasome Core Particle in Complex with Inhibitors
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   Chapter 4 Natural Product and Synthetic Proteasome Inhibitors
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   Chapter 5 Other Proteasome Inhibitors
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   Chapter 6 The Proteasome in Cell-Cycle Regulation
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   Chapter 7 Proteasome Inhibition and Apoptosis
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   Chapter 8 The Proteasome and the COMPARE Algorithm
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    Chapter 9 The Proteasome in Cancer Biology and Therapy
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    Chapter 10 Radiosensitization and Proteasome Inhibition
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    Chapter 11 Proteasome-Dependent Regulation of NF-κB Activation
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    Chapter 12 Bortezomib with Taxanes
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    Chapter 13 Proteasome Inhibitor Therapy in a Brain Tumor Model
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    Chapter 14 Anthracyclines and Bortezomib
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    Chapter 15 TNF-Related Apoptosis-Inducing Ligand (TRAIL)
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    Chapter 16 Rationale for Combining the Proteasome Inhibitor Bortezomib with Cisplatin
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    Chapter 17 Effects of the HIV-1 Protease Inhibitor Ritonavir on Proteasome Activity and Antigen Presentation
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    Chapter 18 Function(s) of the Ubiquitin—Proteasome System in Retrovirus Budding
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    Chapter 19 Preclinical Development of Bortezomib (VELCADE™)
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    Chapter 20 Phase I Trials
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    Chapter 21 Clinical Molecular Diagnostics for Proteasome Inhibitors in Cancer Therapy
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    Chapter 22 Phase II Trials of Bortezomib for the Treatment of Multiple Myeloma