Chapter title |
Staphylococcal Immune Evasion Proteins: Structure, Function, and Host Adaptation
|
---|---|
Chapter number | 5017 |
Book title |
Staphylococcus aureus
|
Published in |
Current topics in microbiology and immunology, January 2016
|
DOI | 10.1007/82_2015_5017 |
Pubmed ID | |
Book ISBNs |
978-3-31-972061-6, 978-3-31-972063-0
|
Authors |
Koymans, Kirsten J, Vrieling, Manouk, Gorham, Ronald D, van Strijp, Jos A G, Kirsten J. Koymans, Manouk Vrieling, Ronald D. Gorham, Jos A. G. van Strijp, Koymans, Kirsten J., Gorham, Ronald D., Strijp, Jos A. G. van |
Abstract |
Staphylococcus aureus is a successful human and animal pathogen. Its pathogenicity is linked to its ability to secrete a large amount of virulence factors. These secreted proteins interfere with many critical components of the immune system, both innate and adaptive, and hamper proper immune functioning. In recent years, numerous studies have been conducted in order to understand the molecular mechanism underlying the interaction of evasion molecules with the host immune system. Structural studies have fundamentally contributed to our understanding of the mechanisms of action of the individual factors. Furthermore, such studies revealed one of the most striking characteristics of the secreted immune evasion molecules: their conserved structure. Despite high-sequence variability, most immune evasion molecules belong to a small number of structural categories. Another remarkable characteristic is that S. aureus carries most of these virulence factors on mobile genetic elements (MGE) or ex-MGE in its accessory genome. Coevolution of pathogen and host has resulted in immune evasion molecules with a highly host-specific function and prevalence. In this review, we explore how these shared structures and genomic locations relate to function and host specificity. This is discussed in the context of therapeutic options for these immune evasion molecules in infectious as well as in inflammatory diseases. |
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Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Netherlands | 1 | 2% |
Germany | 1 | 2% |
Unknown | 43 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 11 | 24% |
Researcher | 8 | 18% |
Student > Master | 5 | 11% |
Professor | 4 | 9% |
Student > Bachelor | 2 | 4% |
Other | 1 | 2% |
Unknown | 14 | 31% |
Readers by discipline | Count | As % |
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Immunology and Microbiology | 9 | 20% |
Agricultural and Biological Sciences | 9 | 20% |
Biochemistry, Genetics and Molecular Biology | 6 | 13% |
Veterinary Science and Veterinary Medicine | 2 | 4% |
Nursing and Health Professions | 1 | 2% |
Other | 5 | 11% |
Unknown | 13 | 29% |