Chapter title |
Physiological Correlates of Bipolar Spectrum Disorders and their Treatment
|
---|---|
Chapter number | 297 |
Book title |
Electrophysiology and Psychophysiology in Psychiatry and Psychopharmacology
|
Published in |
Current topics in behavioral neurosciences, May 2014
|
DOI | 10.1007/7854_2014_297 |
Pubmed ID | |
Book ISBNs |
978-3-31-912768-2, 978-3-31-912769-9
|
Authors |
Tim Outhred, Andrew H. Kemp, Gin S. Malhi, Outhred, Tim, Kemp, Andrew H., Malhi, Gin S. |
Abstract |
Bipolar spectrum disorders (BSDs) are associated with great personal and socioeconomic burden, with patients often facing a delay in detection, misdiagnosis when detected, and a trial-and-error approach to finding the most appropriate treatment. Therefore, improvement in the assessment and management of patients with BSDs is critical. Should valid physiological measures for BSDs be identified and implemented, significant clinical improvements are likely to be realized. This chapter reviews the physiological correlates of BSDs and treatment, and in doing so, examines the neuroimaging, electroencephalogram, and event-related potential, and peripheral physiological correlates that both characterize and differentiate BSDs and their response to treatment. Key correlates of BSDs involve underlying disturbances in prefrontal and limbic network neural activity, early neural processing, and within the autonomic nervous system. These changes appear to be mood-related and can be normalized with treatment. We adopt an "embodied" perspective and propose a novel, working framework that takes into account embodied psychophysiological mechanisms in which the physiological correlates of BSD are integrated. This approach may in time provide the objective physiological measures needed to improve assessment and decision making when treating patients with BSDs. Future research with integrative, multimodal measures is likely to yield potential applications for physiological measures of BSD that correlate closely with diagnosis and treatment. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 3% |
Unknown | 29 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 6 | 20% |
Student > Bachelor | 4 | 13% |
Researcher | 4 | 13% |
Student > Doctoral Student | 2 | 7% |
Other | 2 | 7% |
Other | 5 | 17% |
Unknown | 7 | 23% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 10 | 33% |
Medicine and Dentistry | 9 | 30% |
Neuroscience | 2 | 7% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
Unspecified | 1 | 3% |
Other | 1 | 3% |
Unknown | 6 | 20% |