Chapter title |
Regulation of V(D)J recombination by E-protein transcription factors.
|
---|---|
Chapter number | 12 |
Book title |
V(D)J Recombination
|
Published in |
Advances in experimental medicine and biology, January 2009
|
DOI | 10.1007/978-1-4419-0296-2_12 |
Pubmed ID | |
Book ISBNs |
978-1-4419-0295-5, 978-1-4419-0296-2
|
Authors |
Jones, Mary Elizabeth, Zhuang, Yuan, Pierre Ferrier, Mary Elizabeth Jones, Yuan Zhuang |
Abstract |
Extensive study of the E-proteins E2A and HEB duringlymphocyte development has revealed various functions for these bHLH transcription factors in regulating V(D)J recombination in both B- and T-cells. The study of E-proteins in mammals began with the identification of E2A by its ability to bind immunoglobulin heavy and light chain enhancers. Subsequent analysis has identified numerous roles for E2A and HEB at the immunoglobulin and T-cell receptor loci. E-protein targets also include the rag genes and other factors critical for recombination and for regulation of the developmental windows when cells undergo recombination. E-proteins appear to be master regulators that coordinate antigen receptor gene rearrangement and expression. This chapter focuses on how E-proteins regulate V(D)J recombination by activating transcription, initiating rearrangement and driving differentiation during B- and T-cell development. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 7 | 47% |
Professor > Associate Professor | 3 | 20% |
Student > Doctoral Student | 2 | 13% |
Researcher | 2 | 13% |
Professor | 1 | 7% |
Other | 0 | 0% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 40% |
Biochemistry, Genetics and Molecular Biology | 4 | 27% |
Immunology and Microbiology | 3 | 20% |
Unspecified | 1 | 7% |
Unknown | 1 | 7% |