Chapter title |
Mucins and Cytokeratins as Serum Tumor Markers in Breast Cancer
|
---|---|
Chapter number | 13 |
Book title |
Advances in Cancer Biomarkers
|
Published in |
Advances in experimental medicine and biology, January 2015
|
DOI | 10.1007/978-94-017-7215-0_13 |
Pubmed ID | |
Book ISBNs |
978-9-40-177214-3, 978-9-40-177215-0
|
Authors |
Andrea Nicolini, Paola Ferrari, Giuseppe Rossi |
Abstract |
Structural and functional characteristics of mucins and cytokeratins are shortly described. Thereafter, those commonly used in breast cancer as serum tumor markers are considered. First CA15.3, MCA, CA549, CA27.29 mucins and CYFRA21.1, TPA, TPS cytokeratins alone or in association have been examined in different stages and conditions. Then their usefulness in monitoring disease-free breast cancer patients is evaluated. The central role of the established cut-off and critical change, the "early" treatment of recurrent disease and the potential benefit in survival are other issues that have been highlighted and discussed. The successive sections and subsections deal with the monitoring of advanced disease. In them, the current recommendations and the principal findings on using the above mentioned mucins and cytokeratins have been reported. A computer program for interpreting consecutive measurements of serum tumor markers also has been illustrated. The final part of the chapter is devoted to mucins and cytokeratins as markers of circulating and disseminated tumor cells and their usefulness for prognosis. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 5 | 28% |
Student > Master | 3 | 17% |
Researcher | 2 | 11% |
Professor > Associate Professor | 2 | 11% |
Student > Ph. D. Student | 1 | 6% |
Other | 2 | 11% |
Unknown | 3 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 7 | 39% |
Agricultural and Biological Sciences | 3 | 17% |
Biochemistry, Genetics and Molecular Biology | 2 | 11% |
Immunology and Microbiology | 1 | 6% |
Chemistry | 1 | 6% |
Other | 0 | 0% |
Unknown | 4 | 22% |