Chapter title |
A practical guide to structure-based prediction of MHC-binding peptides.
|
---|---|
Chapter number | 22 |
Book title |
Immunoinformatics
|
Published in |
Methods in molecular biology, January 2007
|
DOI | 10.1007/978-1-60327-118-9_22 |
Pubmed ID | |
Book ISBNs |
978-1-58829-699-3, 978-1-60327-118-9
|
Authors |
Ranganathan, Shoba, Tong, Joo Chuan, Shoba Ranganathan, Joo Chuan Tong |
Abstract |
The binding of bound peptide ligands to major histocompatibility complex (MHC) molecules plays a key role in the activation of normal immune responses and is an intricate theoretical problem that remains unsolved. Geometric and energetic complementarities between an MHC molecule and its corresponding bound peptide ligand are critical in determining the stability of the complex. In this context, the introduction of structural information can greatly facilitate our understanding of how well a peptide ligand can associate with a particular MHC molecule. This chapter introduces the use of structural models as a predictive method to determine whether a peptide sequence can bind to a specific MHC allele. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 6% |
Unknown | 15 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 25% |
Student > Ph. D. Student | 4 | 25% |
Student > Bachelor | 3 | 19% |
Professor > Associate Professor | 2 | 13% |
Student > Doctoral Student | 1 | 6% |
Other | 1 | 6% |
Unknown | 1 | 6% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 10 | 63% |
Medicine and Dentistry | 3 | 19% |
Chemistry | 1 | 6% |
Immunology and Microbiology | 1 | 6% |
Unknown | 1 | 6% |