Chapter title |
Design, synthesis, and screening of biomimetic ligands for affinity chromatography.
|
---|---|
Chapter number | 4 |
Book title |
Chemical Genomics
|
Published in |
Methods in molecular biology, January 2005
|
DOI | 10.1007/978-1-59259-948-6_4 |
Pubmed ID | |
Book ISBNs |
978-1-58829-399-2, 978-1-59259-948-6
|
Authors |
Roque, Ana Cecília A, Gupta, Geeta, Lowe, Christopher R, Roque, Ana Cecília A., Lowe, Christopher R., Ana Cecília A. Roque, Geeta Gupta, Christopher R. Lowe |
Abstract |
Affinity chromatography is ideally suited to the purification of pharmaceutical proteins due to its unique bio-specificity characteristics. Tailor-made affinity ligands that represent a promising class of synthetic affinity ligands have been developed to target specific proteins and designed to mimic peptidal templates, natural biological recognition motifs, or complementary surface-exposed residues. These biomimetic ligands have been generated by a combination of rational design, combinatorial library synthesis, and subsequent screening of potential leads against target proteins. Small ligands based on a triazine scaffold also present exceptional selectivity and stability, which allows their use in harsh manufacturing environments. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Switzerland | 1 | 8% |
Unknown | 11 | 92% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 4 | 33% |
Professor | 2 | 17% |
Student > Ph. D. Student | 2 | 17% |
Professor > Associate Professor | 2 | 17% |
Student > Master | 2 | 17% |
Other | 1 | 8% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 5 | 42% |
Chemical Engineering | 1 | 8% |
Biochemistry, Genetics and Molecular Biology | 1 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Other | 1 | 8% |
Unknown | 2 | 17% |