Chapter title |
Mouse and Other Rodent Models of C to U RNA Editing
|
---|---|
Chapter number | 7 |
Book title |
RNA and DNA Editing
|
Published in |
Methods in molecular biology, February 2015
|
DOI | 10.1007/978-1-61779-018-8_7 |
Pubmed ID | |
Book ISBNs |
978-1-61779-017-1, 978-1-61779-018-8
|
Authors |
Valerie Blanc, Nicholas O. Davidson |
Abstract |
Substitutional RNA editing represents an important posttranscriptional enzymatic pathway for increasing genetic plasticity by permitting production of different translation products from a single genomically encoded template. One of the best-characterized examples in mammals is C to U deamination of the nuclear apolipoprotein B (apoB) mRNA. ApoB mRNA undergoes a single, site-specific cytidine deamination event yielding an edited transcript that results in tissue-specific translation of two distinct isoforms, referred to as apoB100 and apoB48. Tissue- and site-specific cytidine deamination of apoB mRNA is mediated by an incompletely characterized holoenzyme containing a minimal core complex consisting of an RNA-specific cytidine deaminase, Apobec-1 and a requisite cofactor, apobec-1 complementation factor (ACF). The underlying biochemical and genetic mechanisms regulating tissue-specific apoB mRNA editing have been accelerated through development and characterization of physiological rodent models as well as knockout and transgenic animal strains. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Master | 2 | 12% |
Professor > Associate Professor | 2 | 12% |
Student > Ph. D. Student | 2 | 12% |
Researcher | 2 | 12% |
Student > Bachelor | 1 | 6% |
Other | 1 | 6% |
Unknown | 7 | 41% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Medicine and Dentistry | 1 | 6% |
Engineering | 1 | 6% |
Unknown | 7 | 41% |