Report for: Cyclooxygenases

You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.

Chapter title	In vitro assays for cyclooxygenase activity and inhibitor characterization.
Chapter number	11
Book title	Cyclooxygenases
Published in	Methods in molecular biology, July 2010
DOI	10.1007/978-1-59745-364-6_11
Pubmed ID	20645170
Book ISBNs	978-1-58829-953-6, 978-1-59745-364-6
Authors	Walker MC, Gierse JK, Mark C. Walker, James K. Gierse
Abstract	Cyclooxygenases (COX), or Prostaglandin H Synthases (PGHS), are the target enzymes for nonsteroidal anti-inflammatory drugs (NSAIDS). The identification of two isoforms of COX nearly 20 years ago stimulated a flurry of research activity to identify novel, selective inhibitors that could provide potential benefit over existing nonselective NSAIDS. An important contribution to this discovery effort was the development of various in vitro and in vivo assays to support rapid screening of chemical libraries, characterization of inhibitory mechanism, and determination of potency and efficacy to guide follow-up medicinal chemistry efforts. Several assay methods for the in vitro evaluation of COX activity and mechanism of inhibition by test compounds will be reviewed. Each of these methods has inherent advantages and disadvantages with regard to application and the mechanistic detail provided.

View on publisher site Alert me about new mentions

Mendeley readers

The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country	Count	As %
Mexico	1	2%
Unknown	51	98%

Demographic breakdown

Readers by professional status	Count	As %
Student > Ph. D. Student	14	27%
Researcher	10	19%
Student > Bachelor	4	8%
Student > Master	4	8%
Professor > Associate Professor	3	6%
Other	5	10%
Unknown	12	23%

Readers by discipline	Count	As %
Biochemistry, Genetics and Molecular Biology	11	21%
Pharmacology, Toxicology and Pharmaceutical Science	7	13%
Agricultural and Biological Sciences	7	13%
Chemistry	4	8%
Immunology and Microbiology	4	8%
Other	4	8%
Unknown	15	29%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 January 2014.

All research outputs

#20,216,580

of 22,739,983 outputs

Outputs from Methods in molecular biology

#9,853

of 13,087 outputs

Outputs of similar age

#89,864

of 94,531 outputs

Outputs of similar age from Methods in molecular biology

#13

of 15 outputs

Altmetric has tracked 22,739,983 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.

So far Altmetric has tracked 13,087 research outputs from this source. They receive a mean Attention Score of 3.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.

Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 94,531 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.

Cyclooxygenases

Table of Contents

Mentioned by

Citations

Readers on

Mendeley readers

Geographical breakdown

Demographic breakdown

Attention Score in Context