| Chapter title |
Radiation Therapy for Glioma Stem Cells
|
|---|---|
| Chapter number | 6 |
| Book title |
Stem Cell Biology in Neoplasms of the Central Nervous System
|
| Published in |
Advances in experimental medicine and biology, January 2015
|
| DOI | 10.1007/978-3-319-16537-0_6 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-916536-3, 978-3-31-916537-0
|
| Authors |
Anthony E. Rizzo, Jennifer S. Yu, Rizzo, Anthony E., Yu, Jennifer S. |
| Abstract |
Radiation therapy is the most effective adjuvant treatment modality for virtually all patients with high-grade glioma. Its ability to improve patient survival has been recognized for decades. Cancer stem cells provide new insights into how tumor biology is affected by radiation and the role that this cell population can play in disease recurrence. Glioma stem cells possess a variety of intracellular mechanisms to resist and even flourish in spite of radiation, and their proliferation and maintenance appear tied to supportive stimuli from the tumor microenvironment. This chapter reviews the basis for our current use of radiation to treat high-grade gliomas, and addresses this model in the context of therapeutically resistant stem cells. We discuss the available evidence highlighting current clinical efforts to improve radiosensitivity, and newer targets worthy of further development. |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 19 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 21% |
| Researcher | 3 | 16% |
| Student > Bachelor | 3 | 16% |
| Other | 2 | 11% |
| Lecturer | 1 | 5% |
| Other | 3 | 16% |
| Unknown | 3 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 6 | 32% |
| Agricultural and Biological Sciences | 3 | 16% |
| Neuroscience | 2 | 11% |
| Psychology | 1 | 5% |
| Unspecified | 1 | 5% |
| Other | 2 | 11% |
| Unknown | 4 | 21% |