Chapter title |
Expression of cysteine protease inhibitors stefin A, stefin B, and cystatin C in human lung tumor tissue.
|
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Chapter number | 34 |
Book title |
Cellular Peptidases in Immune Functions and Diseases
|
Published in |
Advances in experimental medicine and biology, January 1997
|
DOI | 10.1007/978-1-4757-9613-1_34 |
Pubmed ID | |
Book ISBNs |
978-1-4757-9615-5, 978-1-4757-9613-1
|
Authors |
Ebert, E, Werle, B, Jülke, B, Kopitar-Jerala, N, Kos, J, Lah, T, Abrahamson, M, Spiess, E, Ebert, W, Eileen Ebert, Bernd Werle, Britta Jülke, Natasa Kopitar-Jerala, Janko Kos, Tamara Lah, Magnus Abrahamson, Eberhard Spiess, Werner Ebert, Ebert, Eileen, Werle, Bernd, Jülke, Britta, Kopitar-Jerala, Natasa, Kos, Janko, Lah, Tamara, Abrahamson, Magnus, Spiess, Eberhard, Ebert, Werner |
Abstract |
In human lung tumor tissue specimen (n = 73) concentrations of stefins A and B were found to be increased 2.0-fold (p < 0.01) and 1.3-fold (p < 0.01), respectively, as compared to matched normal tissue. Stefin A and B concentrations were higher in primary tumors than in secondary tumors, i.e. metastases from other organs to the lung (p < 0.01; p < 0.05, respectively). Cystatin C concentrations were rather low and did not differ between tumor and normal tissue. Both concentrations of stefins did not correlate with TNM stages. Stefin A was higher in squamous cell carcinoma than in adenocarcinoma (p < 0.01), while stefin B did not show such a difference. At investigation of a relationship between survival probability of patients with primary tumors it was found that increased stefin B concentrations and total cysteine-protease-inhibitory activities but not stefin A concentrations were positively correlated with survival probability. It is concluded that stefins A and B are major contributors to the cysteine protease inhibitory activity in primary lung tumors. Stefin B proved to be a prognostic factor, especially in squamous cell carcinoma. |
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Demographic breakdown
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Other | 1 | 6% |
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Unknown | 2 | 13% |