Chapter title |
Inhibition of MAO activity, 3H-imipramine binding, 3H-paroxetine binding and 3H-5-HT uptake by human cerebrospinal fluid.
|
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Chapter number | 61 |
Book title |
Amine Oxidases and Their Impact on Neurobiology
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Published in |
Journal of neural transmission Supplementum, January 1990
|
DOI | 10.1007/978-3-7091-9113-2_61 |
Pubmed ID | |
Book ISBNs |
978-3-21-182239-5, 978-3-70-919113-2
|
Authors |
T Egashira, S Goto, F Murayama, Y Yamanaka, T. Egashira, S. Goto, F. Murayama, Y. Yamanaka, Egashira, T., Goto, S., Murayama, F., Yamanaka, Y. |
Abstract |
Addition of small amount of human cerebrospinal fluid (CSF) inhibited both types of MAO in monkey brain mitochondria. The specific binding of 3H-paroxetine decreased remarkably with increasing CSF volumes, while 3H-imipramine binding was slightly inhibited. Scatchard analysis of 3H-paroxetine binding in the presence and absence of CSF indicated that the inhibitory effect was associated with a decreased Bmax without an appreciable change in Kd. Addition of CSF induced an inhibition of uncompetitive 3H-5-HT uptake to monkey cerebral membranes. These results indicate that the materials in human CSF inhibit 3H-paroxetine binding, and modulate the uptake system for 5-HT. |
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Unknown | 1 | 100% |
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Members of the public | 1 | 100% |