Chapter title |
Blood-derived DNA methylation markers of cancer risk.
|
---|---|
Chapter number | 12 |
Book title |
Epigenetic Alterations in Oncogenesis
|
Published in |
Advances in experimental medicine and biology, September 2012
|
DOI | 10.1007/978-1-4419-9967-2_12 |
Pubmed ID | |
Book ISBNs |
978-1-4419-9966-5, 978-1-4419-9967-2
|
Authors |
Marsit C, Christensen B, Carmen Marsit, Brock Christensen, Marsit, Carmen, Christensen, Brock |
Abstract |
The importance of somatic epigenetic alterations in tissues targeted for carcinogenesis is now well recognized and considered a key molecular step in the development of a tumor. Particularly, alteration of gene-specific and genomic DNA methylation has been extensively characterized in tumors, and has become an attractive biomarker of risk due to its specificity and stability in human samples. It also is clear that tumors do not develop as isolated phenomenon in their target tissue, but instead result from altered processes affecting not only the surrounding cells and tissues, but other organ systems, including the immune system. Thus, alterations to DNA methylation profiles detectable in peripheral blood may be useful not only in understanding the carcinogenic process and response to environmental insults, but can also provide critical insights in a systems biological view of tumorigenesis. Research to date has generally focused on how environmental exposures alter genomic DNA methylation content in peripheral blood. More recent work has begun to translate these findings to clinically useful endpoints, by defining the relationship between DNA methylation alterations and cancer risk. This chapter highlights the existing research linking the environment, blood-derived DNA methylation alterations, and cancer risk, and points out how these epigenetic alterations may be contributing fundamentally to carcinogenesis. |
X Demographics
Geographical breakdown
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United Kingdom | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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Malaysia | 1 | 8% |
Unknown | 11 | 92% |
Demographic breakdown
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Student > Ph. D. Student | 3 | 25% |
Researcher | 2 | 17% |
Student > Master | 1 | 8% |
Student > Bachelor | 1 | 8% |
Professor > Associate Professor | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 25% |
Readers by discipline | Count | As % |
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Nursing and Health Professions | 1 | 8% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 8% |
Medicine and Dentistry | 1 | 8% |
Other | 1 | 8% |
Unknown | 3 | 25% |