| Chapter title |
Advanced Technologies in Sialic Acid and Sialoglycoconjugate Analysis.
|
|---|---|
| Chapter number | 458 |
| Book title |
SialoGlyco Chemistry and Biology II
|
| Published in |
Topics in current chemistry, May 2015
|
| DOI | 10.1007/128_2013_458 |
| Pubmed ID | |
| Book ISBNs |
978-3-31-921316-3, 978-3-31-921317-0
|
| Authors |
Kitajima, Ken, Varki, Nissi, Sato, Chihiro, Ken Kitajima, Nissi Varki, Chihiro Sato |
| Abstract |
Although the structural diversity of sialic acid (Sia) is rapidly expanding, understanding of its biological significance has lagged behind. Advanced technologies to detect and probe diverse structures of Sia are absolutely necessary not only to understand further biological significance but also to pursue medicinal and industrial applications. Here we describe analytical methods for detection of Sia that have recently been developed or improved, with a special focus on 9-O-acetylated N-acetylneuraminic acid (Neu5,9Ac), N-glycolylneuraminic acid (Neu5Gc), deaminoneuraminic acid (Kdn), O-sulfated Sia (SiaS), and di-, oligo-, and polysialic acid (diSia/oligoSia/polySia) in glycoproteins and glycolipids. Much more attention has been paid to these Sia and sialoglycoconjugates during the last decade, in terms of regulation of the immune system, neural development and function, tumorigenesis, and aging. |
X Demographics
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 8 | 27% |
| Researcher | 4 | 13% |
| Student > Master | 4 | 13% |
| Student > Doctoral Student | 2 | 7% |
| Lecturer | 1 | 3% |
| Other | 4 | 13% |
| Unknown | 7 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 8 | 27% |
| Agricultural and Biological Sciences | 5 | 17% |
| Chemistry | 3 | 10% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Immunology and Microbiology | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 9 | 30% |