Hemoglobin-Based Oxygen Carriers as Red Cell Substitutes and Oxygen Therapeutics

Table of Contents

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   Book Overview
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   Chapter 1 From Hemoglobin Based Oxygen Carrier to Oxygen Therapeutics, Blood Substitutes, Nanomedicine and Artificial Cells
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   Chapter 2 From the Atmosphere to the Mitochondrion: The Oxygen Cascade
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   Chapter 3 Biochemistry of Hemoglobin
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   Chapter 4 The Role of Blood and Plasma Viscosity in Restoring Oxygen Delivery Capacity
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   Chapter 5 Pathophysiology of Hemorrhagic Shock and Resuscitation
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   Chapter 6 Allogeneic Blood Transfusion for Surgical and Traumatic Hemorrhage
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   Chapter 7 Pre-Hospital Fluid Resuscitation in Civilian and Military Populations
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   Chapter 8 NIH/FDA/DOD Interagency Working Group on Oxygen Therapeutics
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    Chapter 9 Regulatory Framework for Hemoglobin-Based Oxygen Carrier Trials
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    Chapter 10 HBOCs from Chemical Modification of Hb
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    Chapter 11 Design of Nonhypertensive Conjugated Hemoglobins as Novel Resuscitation Fluids
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    Chapter 12 Cellular-Type Hemoglobin-Based Oxygen Carriers to Mimic the Red Blood Cell Structure
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    Chapter 13 Recombinant Octameric Hemoglobins as Resuscitation Fluids in a Murine Model of Traumatic Brain Injury Plus Hemorrhagic Shock
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    Chapter 14 Liposome-Encapsulated Hemoglobin as an Artificial Oxygen Carrier: Technological Features, Manufacturing and Issues for Practical Application
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    Chapter 15 Zero-Link Hemoglobin (OxyVita ® ): Impact of Molecular Design Characteristics on Pre-clinical Studies
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    Chapter 16 Polynitroxylated Pegylated Hemoglobin (PNPH): A Nanomedicine for Critical Care and Transfusion
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    Chapter 17 ATP-Adenosine-GSH Crosslinked Hb, An Oxygen Carrier with Pharmacological Properties for Multiple Therapeutic Indications
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    Chapter 18 Albumin-Heme Oxygen Carriers
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    Chapter 19 Recombinant Human Hb‐SOD Fusion Proteins
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    Chapter 20 In‐Vitro Production of Functional RBCs from Hematopoietic Stem Cells
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    Chapter 21 Liposome-Encapsulated Hemoglobin: Potential Clinical Applications
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    Chapter 22 Biocompatibility of Hemoglobin Vesicles, a Cellular-Type Artificial Oxygen Carrier, on Blood Cells and Plasma Proteins In Vitro and In Vivo
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    Chapter 23 Polymerized Human Placenta Hemoglobin: Organ Protective Effects and Alternative Clinical Uses
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    Chapter 24 Low Volume Resuscitation with HBOCs in Hemorrhagic Shock
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    Chapter 25 Ischemic Rescue with Hemoglobin-Based Oxygen Carriers
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    Chapter 26 Pre-clinical Evaluation of Hemoglobin Based Oxygen Carriers: Animal Models and Biomarkers
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    Chapter 27 The Hemoglobin-Based Oxygen Carrier, HBOC-201, as a Resuscitation Fluid for Traumatic Hemorrhagic Shock: The Naval Medical Research Center Experience
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    Chapter 28 Cellular-Type Hemoglobin-Based Oxygen Carrier as a Resuscitative Fluid for Hemorrhagic Shock: Acute and Long-Term Safety Evaluation Using Beagle Dogs
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    Chapter 29 Key Adverse Events in Recent HBOC Phase III Clinical Trials and Their Causal Relationship to Test HBOC’s
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    Chapter 30 Some Critical Comments on the Major HBOC Clinical Trials
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    Chapter 31 Compassionate Use Cases Treated with Hemoglobin-Based Oxygen Carriers
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    Chapter 32 Acellular Hemoglobin-Based Oxygen Carrier Mediated Blood Pressure Elevation and Vasoconstriction: A Review of Proposed Mechanisms and Contributing Factors
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    Chapter 33 HBOCs and Cardiac Integrity
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    Chapter 34 Effects of Hemoglobin-Based Oxygen Carriers on Blood Coagulation
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    Chapter 35 Redox Activity of Cell-Free Hemoglobin: Implications for Vascular Oxidative Stress and Endothelial Dysfunction
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    Chapter 36 HBOC Interferences with Routine Clinical Laboratory Tests
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    Chapter 37 Vasoconstriction, Hypertension and Oxidative Toxicity are Regulated by Polymerized Hemoglobin Size
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    Chapter 38 Acellular Hemoglobin-Based Oxygen Carrier Induced Vasoactivity: A Brief Review of Potential Pharmacologic Remedies
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    Chapter 39 International Consortium for Development of Hemoglobin-Based Oxygen Carriers, Oxygen Therapeutics and Multifunctional Resuscitation Fluids–A White Paper