Chapter title |
Current Pharmacological Concepts in the Treatment of the Retinitis Pigmentosa
|
---|---|
Chapter number | 54 |
Book title |
Retinal Degenerative Diseases
|
Published in |
Advances in experimental medicine and biology, January 2018
|
DOI | 10.1007/978-3-319-75402-4_54 |
Pubmed ID | |
Book ISBNs |
978-3-31-975401-7, 978-3-31-975402-4
|
Authors |
Xiu-Feng Huang, Huang, Xiu-Feng |
Abstract |
Retinitis pigmentosa (RP) encompasses a heterogeneous group of inherited retinal disorders characterized by progressive photoreceptor and/or retinal pigment epithelial (RPE) degenerations with a prevalence approximately 1 in 4000 in the general population. Over 70 causative genes have been defined in RP families, and a number of animal models have been identified so far. However there have been no widely recognized treatments able to recover or reverse the degenerating retina, to prevent the disease deterioration, ultimately to restore the remaining vision. Therapeutics advancements have been achieved including gene therapy, pharmacotherapy, cell replacement, neurotrophic factors, and retinal prosthesis. In this review, we focus on the pharmaceutical drugs for RP with emphases on the context of drug discovery, development, and clinical translation. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 30 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 5 | 17% |
Student > Bachelor | 4 | 13% |
Other | 3 | 10% |
Student > Ph. D. Student | 3 | 10% |
Unspecified | 2 | 7% |
Other | 5 | 17% |
Unknown | 8 | 27% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 8 | 27% |
Biochemistry, Genetics and Molecular Biology | 4 | 13% |
Pharmacology, Toxicology and Pharmaceutical Science | 3 | 10% |
Unspecified | 2 | 7% |
Nursing and Health Professions | 2 | 7% |
Other | 3 | 10% |
Unknown | 8 | 27% |