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The Target Organ and the Toxic Process

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Cover of 'The Target Organ and the Toxic Process'

Table of Contents

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    Book Overview
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    Chapter 1 In Vitro and In Vivo Research on Phototoxic Xenobiotics: Structure-Reactivity Relationships
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    Chapter 2 Photoallergy, Mechanisms and Models
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    Chapter 3 Human Drug Photosensitivity: Predictive Studies in Guinea Pigs
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    Chapter 4 Photomutagenicity Induced by Psoralens: Mechanism of Repair and Photomutagenicity
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    Chapter 5 Photomutagenicity Induced by Psoralens: Modulation of the Photomutagenic Response in Eukaryotes
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    Chapter 6 Chemical Modifiers of Photocarcinogenesis
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    Chapter 7 Photogenotoxicity of Bergamot Oil in Salmonella Typhimurium TA102 and in V79 Chinese Hamster Cells: Efficiency Assessment of Filter Protective Effect
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    Chapter 8 DNA Damage Caused by Laser Light Activated Hematoporphyrin Derivatives in Isolated Nuclei of Human Melanoma Cells
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    Chapter 9 Systemic Photobiological Effects of Xenobiotics
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    Chapter 10 Photomutagenic Effect Induced by 4,4′,6-Trimethylangelicin in Salmonella typhimurium TA 102 and Saccharomyces cerevisiae D7
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    Chapter 11 Mechanistic Studies on the Thyroid Toxicity Induced by Certain Drugs
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    Chapter 12 Comparison of the Effects of SK&F 93479 and Phenobarbitone Treatment on Thyroid Toxicity and Hepatic Thyroid Hormone Metabolising Enzymes in the Rat
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    Chapter 13 Thyroid Hyperactivity Caused by Hypolipodaemic Compounds and Polychlorinated Biphenyls: The Effect of Coadministration in the Liver and Thyroid
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    Chapter 14 The Effect of Sodium Bromide on Thyroid Function
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    Chapter 15 Hyperplastic and Neoplastic Responses of the Thyroid Gland in Toxicological Studies
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    Chapter 16 Chronic Zinc Ethylenebisdithiocarbamate Toxicity in Calves: Effects on the Thyroid and Clinicopathological Findings
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    Chapter 17 Lymphocytic Thyroiditis in Beagle Dogs
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    Chapter 18 Nephrotoxicity of Antitumoral Agents
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    Chapter 19 Effect of Cadmium Ions on Na/K-ATPase Activity in a Defined Segment of the Rabbit Proximal Tubule
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    Chapter 20 In Vivo and In Vitro Assessment of Vancomycin-Induced Nephrotoxicity
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    Chapter 21 Renal Papillary Necrosis and Upper Urothelial Carcinoma
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    Chapter 22 Age-Dependent Differences in Nephrotoxicity of Xenobiotics
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    Chapter 23 Chronobiological Approach to Aminoglycosides
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    Chapter 24 Effects of Puromycin Aminonucleoside on Ten Urinary Enzymes in Rats
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    Chapter 25 Monoclonal Antibodies to Brush Border Antigens for the Early Diagnosis of Nephrotoxicity
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    Chapter 26 Effects of Cisplatin and Carboplatin on Cell Cultures of Renal and Non-renal Origin
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    Chapter 27 Reduction of Cisplatin Nephrotoxicity by Selenium: Does Metallothionein Play a Role?
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    Chapter 28 The Relationships Between Plasma Cyclosporin Levels and Renal Tubulotoxicity Assessed by Enzymuria After Liver Transplantation
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    Chapter 29 Renal Function in Lithium Treatment
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    Chapter 30 In Vitro Study and Conformational Analysis of 1- N -Aminohydroxybutyryl Derivatives of Aminoglycosides in Correlation with Their Inhibitory Potency Towards Lysosomal Phospholipases
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    Chapter 31 Proximal Tubule Brush Border Angiotensin Converting Enzyme Behaviour and Nephrotoxicity Due to 1,2-Dichloropropane
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    Chapter 32 Effects of Subsequent Peroral or Intravenous (“Refill”) Cholegraphy on Kidney Function in Dogs
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    Chapter 33 Dichlorovinylcysteine-Induced Nephrotoxicity: Role of Peroxidative Injury
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    Chapter 34 In Vivo Studies on the Relationship Between Hepatic Metabolism and Toxicity of Ochratoxin A
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    Chapter 35 Hepatic Peroxisome Proliferation: An Overview
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    Chapter 36 Structure-Activity Relationships for Hepatic Peroxisome Proliferation
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    Chapter 37 Influence of Drugs on Liver Mitochondria and Peroxisomes
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    Chapter 38 Effects of Adipates, Phthalates, and Fibrates on Liver Enzymes and Peroxisomes in a Variety of Mammalian Species
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    Chapter 39 Mechanisms of Tumor Induction by Peroxisome Proliferators
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    Chapter 40 Concomitant Induction of Cytosolic Epoxide Hydrolase and Peroxisomal β-Oxidation by Hypolipidemic Compounds in Rat and Guinea Pig Liver
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    Chapter 41 A Dicarboxylic Acid Derivative of the Hypolipidemic Peroxisome Proliferator, Tiadenol, Triggers Induction of Long-Chain Fatty Acid Metabolising Enzymes and Peroxisomal β-Oxidation
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    Chapter 42 A Dicarboxylic Metabolite of Tiadenol, Bis-(carboxyethylthio)-1,10 Decane, Which Causes Hypolipidemia and Proliferation of Peroxisomes When Administered to Rodents, Is Activated to an Acyl-coenzyme A Thioester
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    Chapter 43 In Vivo and In Vitro Metabolism of Di-(2-ethylhexyl) Adipate a Peroxisome Proliferator, in the Rat
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    Chapter 44 Allyl Alcohol and Acrolein Toxicity in Isolated Rat Hepatocytes is Independent of Lipid Peroxidation
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    Chapter 45 Di-(2-ethylhexyl) Adipate and Peroxisome Proliferation: Identification of Proximate Peroxisomal Proliferator In Vivo and In Vitro
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    Chapter 46 The Effect of Ethionine on Peroxisome-Associated Enzymes
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    Chapter 47 Immunoaffinity Purification and Comparison of Epoxide Hydrolases from Liver Cytosol and Peroxisomes of Untreated and Clofibrate-Treated Mice
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    Chapter 48 Induction of Cytosolic and Microsomal Epoxide Hydrolases in Murine Liver by Known Peroxisome Proliferators and Structurally Related Substances
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    Chapter 49 Enterohepatic Circulation of Fenofibrate Metabolites in the Rat, a Peroxisome Proliferator Responsive Species
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    Chapter 50 The Effect of Clofibrate Feeding on Enzyme Activities and Mitochondrial Protein Content in Rat Liver and Renal Cortex
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    Chapter 51 Anticancer Drug Toxicity in the Absence of Hypophyseal or Adrenal Secretion
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    Chapter 52 Studies on Human Blood Myeloperoxidase and Peroxidase from Rat Uterus, Intestine, and Spleen
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    Chapter 53 Biotransformations of γ-Picoline in the Rat
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    Chapter 54 Enzymatic and/or Non-Enzymatic “Suicidal” Activation of Carbon Tetrachloride by Heam and Cytochrome P-450
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    Chapter 55 Method for Assessment of Experimental Allergy in Guinea Pigs Adapted to Cosmetic Ingredients
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    Chapter 56 Immunotoxicotherapy for Colchicine Poisoning: Toxicological and Pharmacological Features of an Experimental Model Simulating Human Poisoning
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    Chapter 57 Cardiovascular Actions of Lead in Rats as Related to the Level of Chronic Exposure
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    Chapter 58 Detection of DNA Damage Induced by Doxorubicin and the Effect of Glutathione
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    Chapter 59 Chromosome Aberrations in Human Lymphocytes with a New Resin Composite for Aerospace Use
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    Chapter 60 Testing of 2,4,5- and 2,4,6-Trimethylaniline in the Salmonella Assay, in Mammalian Cell Cultures, and in Drosophila melanogaster , and Comparison of the Results with Carcinogenicity Data
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    Chapter 61 Base Substitution Mutations Induced by the Mycotoxin Citrinin
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    Chapter 62 Toxicity and Mutagenicity of Patulin in Different Test Systems
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    Chapter 63 The Combined Acute Toxicity of Lonidamine with Some Other Anticancer Agents or Acetylsalicylic Acid
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    Chapter 64 Cytotoxicity of Simple Geiparvarin Analogues
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    Chapter 65 Epoxide Metabolites of Opiates and Their Interaction with the Hepatic Microsomal Epoxide Hydrolase
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    Chapter 66 Purification and Characterization of Acidic Glutathione S -Transferases (EC 2.5.1.18) from Rat Kidney
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    Chapter 67 1,2-Dichloropropane-Induced Liver Toxicity: Clinical Data and Preliminary Studies in Rats
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    Chapter 68 Induction of Hepatic Metallothionein Following Acetaminophen Administration
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    Chapter 69 The Effect of Cimetidine or Phenobarbital on the Hepatotoxicity of Citalopram in Male Rats
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    Chapter 70 Quantitative Morphology of Hepatocyte Nuclei in the Comparative Studies of Di(2-ethylhexyl)phthalate Effects
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    Chapter 71 Organic Solvents Affect Rat Synaptosome Membrane Acetylcholinesterase and Adenosine Triphosphatase In Vitro
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    Chapter 72 Effect of 2-Methyl-4-chlorophenoxyacetic Acid on Liver Catalase in Chicken Embryos
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    Chapter 73 β-Cyclodextrin and Local Muscle Toxicity of Intramuscular Drug Formulations
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    Chapter 74 Determination of Ethyl Loflazepate, an Anxiolytic Benzodiazepine, in Human Plasma by High-Performance Liquid Chromatography
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    Chapter 75 Determination of Cocaine in Hair After Repeated Administration to Sheep
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    Chapter 76 Analysis of Ethanol in Blood: A Comparison of the Abbott TD X TM Ethanol Assay with Gas Chromatography and Chemical Assays
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    Chapter 77 Comparative Toxicity of Three Quinoxaline-di-N-dioxide Feed Additives in Young Pigs
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    Chapter 78 Cardiotoxicity of Doxorubicin: A Histochemical and Morphometric Approach
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    Chapter 79 Inhomogeneous 60 Co Whole Body Irradiation of the Göttinger Miniature Swine: A Model for the Study of Long-Term Immunomodulating Effects
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    Chapter 80 Toxicological Studies with Amrinone
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    Chapter 81 Puffing Patterns of Smokers Switching to Low-Yield Cigarettes: A Controlled Cross-over Study on Diurnal Changes in Behaviour
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    Chapter 82 Effect of Pyridinium, 1 — {[(3-benzoylpyridinio) — methoxy]methyl} — 2 — [(hydroxyimino)methyl] — dichloride (HGG 12) on Various Respiratory and Circulatory Parameters of Anesthetized Guinea Pigs
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    Chapter 83 Comparative Toxicity of Two Trialkylphosphorothioates to Rat Lung and the Effects of Atropine Sulphate Pretreatment
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    Chapter 84 Urinary Mercury Levels and Renal Function Changes in Dentists and Dental Assistants
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    Chapter 85 Comparison of the Effects of Sodium N -Benzyl-D-glucamine Dithiocarbamate and Ditripentat on the Toxicity, Excretion, and Tissue Distribution of Cadmium in Mice
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    Chapter 86 Is the Noxious Hemolytic Effect of Copper a Result of Lipoperoxidation?
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    Chapter 87 Effects of Cobalt, Indium, and Nickel on 7-Ethoxycoumarin- O -Deethylase in Mice
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    Chapter 88 Chronic Lead Treatment and Ultrastructure of the Testis in Rats
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    Chapter 89 Enzyme-Linked Immunosorbent Assay for Detection of Clostridium difficile Toxin B
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Title
The Target Organ and the Toxic Process
Published by
Springer Berlin Heidelberg, December 2012
DOI 10.1007/978-3-642-73113-6
ISBNs
978-3-54-018512-3, 978-3-64-273113-6
Editors

Chambers, Philip L., Chambers, Claire M., Dirheimer, Guy