Chapter title |
Female reproduction in mice lacking the prostaglandin F receptor. Roles of prostaglandin and oxytocin receptors in parturition.
|
---|---|
Chapter number | 39 |
Book title |
Vasopressin and Oxytocin
|
Published in |
Advances in experimental medicine and biology, January 1998
|
DOI | 10.1007/978-1-4615-4871-3_39 |
Pubmed ID | |
Book ISBNs |
978-1-4613-7210-3, 978-1-4615-4871-3
|
Authors |
Y. Sugimoto, E. Segi, K. Tsuboi, A. Ichikawa, S. Narumiya, Sugimoto, Y., Segi, E., Tsuboi, K., Ichikawa, A., Narumiya, S. |
Abstract |
Female mice lacking the receptor for prostaglandin F2 alpha (FP) do not deliver fetuses at term, although these can be successfully rescued by cesarean section. No induction of oxytocin receptor mRNA is found in the uterus of these mice, and they show no uterine contraction on intravenous administration of oxytocin. Furthermore, a decline in serum progesterone levels during the periparturition period is not observed in these animals. Ovariectomy at day 19 of pregnancy restored induction of the oxytocin receptor and caused successful delivery in these animals. These results indicate not only the essential role of luteolytic PGF 2 alpha action in natural parturition but also the importance of oxytocin receptor induction in this process. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 3 | 30% |
Student > Master | 2 | 20% |
Professor | 1 | 10% |
Researcher | 1 | 10% |
Professor > Associate Professor | 1 | 10% |
Other | 1 | 10% |
Unknown | 1 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 20% |
Agricultural and Biological Sciences | 2 | 20% |
Immunology and Microbiology | 2 | 20% |
Medicine and Dentistry | 2 | 20% |
Unknown | 2 | 20% |