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Mendeley readers
Attention Score in Context
| Title |
Serotonin uptake inhibitors attenuate ethanol intake in problem drinkers.
|
|---|---|
| Published in |
Recent developments in alcoholism an official publication of the American Medical Society on Alcoholism the Research Society on Alcoholism and the National Council on Alcoholism, January 1989
|
| DOI | 10.1007/978-1-4899-1678-5_13 |
| Pubmed ID | |
| Authors |
C A Naranjo, E M Sellers |
| Abstract |
There are several problems with the drugs currently used to decrease alcohol consumption (i.e., alcohol-sensitizing drugs, such as disulfiram). Their efficacy is unproven, they are associated with toxicity, and there are several contraindications for use. New therapies are needed because alcohol-related problems affect almost 20% of the adult population. A new strategy was developed that involves attenuation of alcohol intake via serotonin uptake inhibitors. Since several experiments showed that serotonin uptake inhibitors consistently attenuated ethanol intake in rats, we tested their effects in humans. In four randomized, double-blind, placebo-controlled studies serotonin uptake inhibitors (zimelidine, citalopram, viqualine, and fluoxetine) decreased total number of drinks consumed by early stage problem drinkers by an average of 20-30%. However, marked interindividual variations in the pattern of response to serotonin uptake inhibitors have been observed, and we have been unable to identify subject traits or drug factors that predict pattern of response. Effects on ethanol intake are distinct from the antidepressant properties of these drugs, and they are most likely due to facilitation of satiety signals. Because of these promising and consistent results, further testing in a therapeutic context is under way. Serotonin uptake inhibitors suggest an innovative approach for moderating ethanol intake in problem drinkers. |
Mendeley readers
The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 21 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 3 | 14% |
| Professor | 3 | 14% |
| Student > Bachelor | 2 | 10% |
| Researcher | 2 | 10% |
| Other | 2 | 10% |
| Other | 4 | 19% |
| Unknown | 5 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 4 | 19% |
| Pharmacology, Toxicology and Pharmaceutical Science | 3 | 14% |
| Neuroscience | 3 | 14% |
| Medicine and Dentistry | 3 | 14% |
| Economics, Econometrics and Finance | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 6 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 July 2023.
All research outputs
#8,041,340
of 24,171,511 outputs
Outputs from Recent developments in alcoholism an official publication of the American Medical Society on Alcoholism the Research Society on Alcoholism and the National Council on Alcoholism
#11
of 25 outputs
Outputs of similar age
#10,903
of 56,006 outputs
Outputs of similar age from Recent developments in alcoholism an official publication of the American Medical Society on Alcoholism the Research Society on Alcoholism and the National Council on Alcoholism
#1
of 3 outputs
Altmetric has tracked 24,171,511 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 25 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.6. This one scored the same or higher as 14 of them.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 56,006 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 21st percentile – i.e., 21% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 3 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them