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Alzheimer: 100 Years and Beyond

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Cover of 'Alzheimer: 100 Years and Beyond'

Table of Contents

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    Book Overview
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    Chapter 1 Concerning a unique disease of the cerebral cortex
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    Chapter 2 The history of Alois Alzheimer’s first case Auguste D.
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    Chapter 3 Alois Alzheimer and the beginnings of research into Alzheimer’s disease
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    Chapter 4 Alois Alzheimer and the myth of the pioneer
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    Chapter 5 Alzheimer’s Disease at mid-Century (1927–1977) and a little more
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    Chapter 6 A chapter in the development on Alzheimer’s disease research
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    Chapter 7 Anatomical changes underlying dementia in Alzheimer’s disease
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    Chapter 8 Staging of cortical neurofibrillary inclusions of the Alzheimer’s type
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    Chapter 9 Of stains and brains: a brief account of how microscopic and clinical observations contributed to the understanding of Alzheimer’s disease
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    Chapter 10 Presenile forms of Alzheimer’s disease in 2006
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    Chapter 11 The cholinergic deficit in Alzheimer’s disease
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    Chapter 12 Acetylcholine in AD: Expectations meet reality
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    Chapter 13 The Discovery of β Amyloid
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    Chapter 14 Pathways to the discovery of the neuronal origin and proteolytic biogenesis of Aβ amyloid of Alzheimer’s disease
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    Chapter 15 The Amyloid Hypothesis: history and alternatives
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    Chapter 16 Segregation of a missense mutation in the amyloid β-protein precursor gene with familial Alzheimer’s disease
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    Chapter 17 From the amyloid β protein (A4) to isolation of the first Alzheimer’s disease gene: amyloid β (A4) precursor protein (APP)
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    Chapter 18 Commentary on “Correlative memory deficits, Aβ elevation, and amyloid plaques in transgenic mice”
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    Chapter 19 Vision for the future
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    Chapter 20 PS1 , PS2 , and APP mutations that cause Alzheimer’s disease increase Aβ42
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    Chapter 21 Amyloid precursor protein, Alzheimer’s disease, and Down’s syndrome
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    Chapter 22 Catabolism of amyloid β peptide and pathogenesis of sporadic Alzheimer’s disease: towards understanding the underlying mechanisms
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    Chapter 23 Synaptic activity, amyloid-β and Alzheimer’s disease
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    Chapter 24 Molecular pathogenesis of Alzheimer’s disease in human peripheral cells: platelets show it all!
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    Chapter 25 The neuronal origin hypothesis of cerebral amyloid angiopathy
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    Chapter 26 A neuropathologist and Alzheimer genetics
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    Chapter 27 Genetics, molecular biology, and animal modeling of Alzheimer’s disease
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    Chapter 28 The genetic Alzheimer-frontotemporal dementia spectrum
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    Chapter 29 Mutation of the Alzheimer’s disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. The role of amyloid in dementia and stroke
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    Chapter 30 Physiological generation of Amyloid β-peptide and its Consequences for Alzheimer’s disease research
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    Chapter 31 Activation of α-secretase as an approach for treatment of Alzheimer’s disease
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    Chapter 32 Challenges to the enigma of γ-secretase and to Alzheimer’s disease
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    Chapter 33 Targeting γ-Secretase for Alzheimer’s Disease
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    Chapter 34 The Presenilin/gamma-secretase complex and its potential as a drug target in Alzheimer’s Disease
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    Chapter 35 Identification of β-secretase
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    Chapter 36 Apolipoprotein E and Alzheimer’s disease: A brief retrospective
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    Chapter 37 Apolipoprotein E4: From synaptic remodeling to genetic risk factor in both familial and sporadic Alzheimer’s disease
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    Chapter 38 Alzheimer: 100 Years and Beyond
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    Chapter 39 Immunological demonstration of tau protein in neurofibrillary tangles
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    Chapter 40 Bulk isolation of neurofibrillary tangles and discoveries of tau and its abnormal hyperphosphorylation
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    Chapter 41 The natural and molecular history of Alzheimer’s disease: Tau is part of the story
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    Chapter 42 Tau focused drug discovery for Alzheimer’s disease and related Neurodegenerative Tauopathies
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    Chapter 43 Ubiquitin is a component of paired helical filaments in Alzheimer’s disease
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    Chapter 44 Influence of tau on neuronal traffic mechanisms
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    Chapter 45 The Search for structure of tau and paired helical filaments
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    Chapter 46 The Changing landscape of Alzheimer’s disease: From Insoluble to Soluble and from Pathogen to Protector
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    Chapter 47 Molecular and cellular pathways towards and away from Alzheimer’s disease
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    Chapter 48 Paquid: an integrated, multidisciplinary, population-based approach to normal and pathological cerebral aging
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    Chapter 49 Hippocampal imaging in the early diagnosis of AD, 1988 to 2006
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    Chapter 50 Detecting Early-Stage Alzheimer’s Disease in MCI and PreMCI: The value of informants
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    Chapter 51 Imaging the pathology of Alzheimer’s disease: Building on a century-Old blueprint
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    Chapter 52 How do we test drugs?
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    Chapter 53 Inflammation and the lesions of Alzheimer’s disease
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    Chapter 54 Aβ immunotherapy prevents and Reverses Alzheimer’s disease neuropathology
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    Chapter 55 Immunotherapy of Alzheimer’s disease
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    Chapter 56 “Magic” bullets, shotguns or cocktails to treat or prevent Alzheimer’s disease?
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    Chapter 57 The seventh age of man: Solving senility
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    Chapter 58 Fondation Ipsen and Alzheimer’s disease: a 20-year relationship
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    Chapter 59 Alzheimer Research Forum: A Knowledge Base and e-Community for AD Research
Overall attention for this book and its chapters
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Mentioned by

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2 Wikipedia pages

Citations

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16 Dimensions

Readers on

mendeley
54 Mendeley
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1 CiteULike
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Title
Alzheimer: 100 Years and Beyond
Published by
Springer Berlin Heidelberg, November 2006
DOI 10.1007/978-3-540-37652-1
ISBNs
978-3-54-037651-4, 978-3-54-037652-1
Editors

Jucker, Mathias, Beyreuther, Konrad, Haass, Christian, Nitsch, Roger M., Christen, Yves

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Germany 2 4%
Mexico 1 2%
Portugal 1 2%
Korea, Republic of 1 2%
Unknown 49 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 13 24%
Student > Bachelor 8 15%
Researcher 7 13%
Student > Master 6 11%
Student > Doctoral Student 4 7%
Other 6 11%
Unknown 10 19%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 22%
Neuroscience 9 17%
Biochemistry, Genetics and Molecular Biology 5 9%
Psychology 3 6%
Pharmacology, Toxicology and Pharmaceutical Science 2 4%
Other 11 20%
Unknown 12 22%