Chapter title |
A monoclonal antibody with selectivity for human kappa myeloma and lymphoma cells which has potential as a therapeutic agent.
|
---|---|
Chapter number | 101 |
Book title |
Microenvironments in the Lymphoid System
|
Published in |
Advances in experimental medicine and biology, January 1985
|
DOI | 10.1007/978-1-4613-2463-8_101 |
Pubmed ID | |
Book ISBNs |
978-1-4612-9495-5, 978-1-4613-2463-8
|
Authors |
Walker, K Z, Boux, H A, Hayden, G E, Goodnow, C C, Raison, R L, K. Z. Walker, H. A. Boux, G. E. Hayden, C. C. Goodnow, R. L. Raison, Walker, K. Z., Boux, H. A., Hayden, G. E., Goodnow, C. C., Raison, R. L. |
Abstract |
K-1-21 is a monoclonal antibody which binds to human free kappa light chains and recognises a determinant, KMA selectively expressed on kappa myeloma and lymphoma cells. KMA is absent on plasma cells and resting B cells from normal adults but can be detected on some foetal B cells and a small proportion of activated B cells. Expression of KMA is greatest on cycling cells. K-1-21 is an IgG1 antibody that elicits ADCC but will not cap the KMA determinant unless a second ligand is present. K-1-21 has potential for practical application. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 1 | 33% |
Researcher | 1 | 33% |
Other | 1 | 33% |
Student > Master | 1 | 33% |
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Agricultural and Biological Sciences | 2 | 67% |
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Immunology and Microbiology | 1 | 33% |