Chapter title |
Glycoxidative stress creates a vicious cycle of neurodegeneration in Alzheimer's disease--a target for neuroprotective treatment strategies?
|
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Chapter number | 28 |
Book title |
Ageing and Dementia Current and Future Concepts
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Published in |
Journal of neural transmission Supplementum, January 2002
|
DOI | 10.1007/978-3-7091-6139-5_28 |
Pubmed ID | |
Book ISBNs |
978-3-21-183796-2, 978-3-70-916139-5
|
Authors |
G Münch, W Deuther-Conrad, J Gasic-Milenkovic, Münch, G., Deuther-Conrad, W., Gasic-Milenkovic, J., G. Münch, W. Deuther-Conrad, J. Gasic-Milenkovic |
Abstract |
Accumulation of Advanced Glycation Endproducts (AGEs) in the brain is a feature of ageing and degeneration, especially in Alzheimer's disease (AD). Increased AGE levels explain many of the neuropathological and biochemical features of AD such as extensive protein crosslinking (beta-amyloid and MAP-tau), glial activation, oxidative stress and neuronal cell death. Oxidative stress and AGEs initiate a positive feedback loop, where normal age-related changes develop into a pathophysiological cascade. Combined intervention using antioxidants, anti-inflammatory drugs and AGE-inhibitors may be a promising neuroprotective strategy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 17 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 18% |
Professor | 2 | 12% |
Student > Ph. D. Student | 2 | 12% |
Student > Doctoral Student | 1 | 6% |
Other | 1 | 6% |
Other | 4 | 24% |
Unknown | 4 | 24% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 6 | 35% |
Biochemistry, Genetics and Molecular Biology | 2 | 12% |
Medicine and Dentistry | 2 | 12% |
Immunology and Microbiology | 1 | 6% |
Social Sciences | 1 | 6% |
Other | 1 | 6% |
Unknown | 4 | 24% |