Chapter title |
The g protein-coupled receptor rhodopsin: a historical perspective.
|
---|---|
Chapter number | 1 |
Book title |
Rhodopsin
|
Published in |
Methods in molecular biology, January 2015
|
DOI | 10.1007/978-1-4939-2330-4_1 |
Pubmed ID | |
Book ISBNs |
978-1-4939-2329-8, 978-1-4939-2330-4
|
Authors |
Lukas Hofmann, Krzysztof Palczewski, Hofmann, Lukas, Palczewski, Krzysztof |
Abstract |
Rhodopsin is a key light-sensitive protein expressed exclusively in rod photoreceptor cells of the retina. Failure to express this transmembrane protein causes a lack of rod outer segment formation and progressive retinal degeneration, including the loss of cone photoreceptor cells. Molecular studies of rhodopsin have paved the way to understanding a large family of cell-surface membrane proteins called G protein-coupled receptors (GPCRs). Work started on rhodopsin over 100 years ago still continues today with substantial progress made every year. These activities underscore the importance of rhodopsin as a prototypical GPCR and receptor required for visual perception-the fundamental process of translating light energy into a biochemical cascade of events culminating in vision. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 40 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 10 | 25% |
Student > Bachelor | 7 | 18% |
Researcher | 4 | 10% |
Student > Master | 3 | 8% |
Other | 2 | 5% |
Other | 6 | 15% |
Unknown | 8 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 7 | 18% |
Biochemistry, Genetics and Molecular Biology | 7 | 18% |
Neuroscience | 6 | 15% |
Chemistry | 4 | 10% |
Medicine and Dentistry | 4 | 10% |
Other | 3 | 8% |
Unknown | 9 | 23% |