Chapter title |
bcl-1, bcl-2, p53, c-myc, and lyt-10 analysis in cutaneous lymphomas.
|
---|---|
Chapter number | 19 |
Book title |
Skin Cancer: Basic Science, Clinical Research and Treatment
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Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 1995
|
DOI | 10.1007/978-3-642-78771-3_19 |
Pubmed ID | |
Book ISBNs |
978-3-64-278773-7, 978-3-64-278771-3
|
Authors |
Garatti, S A, Roscetti, E, Trecca, D, Fracchiolla, N S, Neri, A, Berti, E, Garatti, S. A., Roscetti, E., Trecca, D., Fracchiolla, N. S., Neri, A., Berti, E. |
Abstract |
In the present study we investigated the pathogenetic role of c-myc, bcl-2, and lyt-10 oncogenes, bcl-1 locus, and p53 suppressor gene in a representative panel of cutaneous lymphomas, including 25 cases of cutaneous B cell lymphoma (CBCL) and 29 cases of cutaneous T cell lymphoma (CTCL). In our analysis four cases of CBCL were found rearranged for bcl-2 and two for the bcl-1 locus. Two cases of CTCL and one case of CBCL were found rearranged for lyt-10. No rearrangements of c-myc oncogene were found in CBCL. Analysis of p53 gene showed mutation only in one case of mycosis fungoides in tumoral stage, at codon 163 of p53 gene (TAC-->CAC; Tyr--> Asp). Our data suggest that in primary CBCL bcl-2 oncogenes and bcl-1 locus are rarely involved. Furthermore, in primary CTCL p53 gene is not affected at significant frequency. The occurrence of p53 mutation in a patient affected by mycosis fungoides in tumoral stage may represent an involvement of p53 gene in tumor progression of CTCL, a finding observed in several types of human cancer. |
Mendeley readers
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