↓ Skip to main content

The Vascular Endothelium I

Overview of attention for book
Attention for Chapter 7: Nitric oxide and the vascular endothelium.
Altmetric Badge

About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Among the highest-scoring outputs from this source (#42 of 645)
  • High Attention Score compared to outputs of the same age (97th percentile)

Mentioned by

2 news outlets
1 blog


22 Dimensions

Readers on

150 Mendeley
1 CiteULike
1 Connotea
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Chapter title
Nitric oxide and the vascular endothelium.
Chapter number 7
Book title
The Vascular Endothelium I
Published in
Handbook of experimental pharmacology, September 2006
DOI 10.1007/3-540-32967-6_7
Pubmed ID
Book ISBNs
978-3-54-032966-4, 978-3-54-032967-1

Moncada S, Higgs EA, Moncada, S., Higgs, E. A., S. Moncada, E. A. Higgs


The vascular endothelium synthesises the vasodilator and anti-aggregatory mediator nitric oxide (NO) from L-arginine. This action is catalysed by the action of NO synthases, of which two forms are present in the endothelium. Endothelial (e)NOS is highly regulated, constitutively active and generates NO in response to shear stress and other physiological stimuli. Inducible (i)NOS is expressed in response to immunological stimuli, is transcriptionally regulated and, once activated, generates large amounts of NO that contribute to pathological conditions. The physiological actions of NO include the regulation of vascular tone and blood pressure, prevention of platelet aggregation and inhibition of vascular smooth muscle proliferation. Many of these actions are a result of the activation by NO of the soluble guanylate cyclase and consequent generation of cyclic guanosine monophosphate (cGMP). An additional target of NO is the cytochrome c oxidase, the terminal enzyme in the electron transport chain, which is inhibited by NO in a manner that is reversible and competitive with oxygen. The consequent reduction of cytochrome c oxidase leads to the release of superoxide anion. This may be an NO-regulated cell signalling system which, under certain circumstances, may lead to the formation of the powerful oxidant species, peroxynitrite, that is associated with a variety of vascular diseases.

Mendeley readers

The data shown below were compiled from readership statistics for 150 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Brazil 2 1%
Italy 1 <1%
Bolivia, Plurinational State of 1 <1%
India 1 <1%
United Kingdom 1 <1%
Unknown 144 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 28 19%
Student > Master 22 15%
Student > Bachelor 19 13%
Researcher 14 9%
Student > Doctoral Student 10 7%
Other 31 21%
Unknown 26 17%
Readers by discipline Count As %
Agricultural and Biological Sciences 25 17%
Medicine and Dentistry 25 17%
Biochemistry, Genetics and Molecular Biology 17 11%
Unspecified 11 7%
Pharmacology, Toxicology and Pharmaceutical Science 8 5%
Other 34 23%
Unknown 30 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 27. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2020.
All research outputs
of 22,758,248 outputs
Outputs from Handbook of experimental pharmacology
of 645 outputs
Outputs of similar age
of 67,460 outputs
Outputs of similar age from Handbook of experimental pharmacology
of 1 outputs
Altmetric has tracked 22,758,248 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 645 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 9.2. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 67,460 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them