Chapter title |
Biosynthesis of myelin and neurotoxic factors in the serum of multiple sclerosis patients.
|
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Chapter number | 2 |
Book title |
Myelination and Demyelination
|
Published in |
Advances in experimental medicine and biology, January 1978
|
DOI | 10.1007/978-1-4684-2514-7_2 |
Pubmed ID | |
Book ISBNs |
978-1-4684-2516-1, 978-1-4684-2514-7
|
Authors |
Davison, A N, Sabri, M I, Davison, A. N., Sabri, M. I., A. N. Davison, M. I. Sabri |
Abstract |
The in vitro synthesis of myelin proteins has been studied by measuring the incorporation of [3H] lysine in developing rat brain slices. This incorporation system has been used to assay potentially gliotoxic and myelinolytic agents. A reduced incorporation of the labelled amino acid into myelin proteins occurs in the presence of anti-myelin anti-serum and anti-basic protein anti-serum. Diphtheria toxin has been found to inhibit the synthesis of myelin basic and proteolipid protein in the white matter slices of developing rats. Recent experiments with serum samples from multiple sclerosis patients in exacerbation suggest the presence of a factor which interferes with the synthesis of myelin in white matter slices. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Professor > Associate Professor | 3 | 75% |
Unknown | 1 | 25% |
Readers by discipline | Count | As % |
---|---|---|
Neuroscience | 2 | 50% |
Agricultural and Biological Sciences | 1 | 25% |
Unknown | 1 | 25% |