Chapter title |
Excretion of polyamines by children with leukemia during chemotherapy.
|
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Chapter number | 31 |
Book title |
Modified Nucleosides and Cancer
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 1983
|
DOI | 10.1007/978-3-642-81947-6_31 |
Pubmed ID | |
Book ISBNs |
978-3-64-281949-0, 978-3-64-281947-6
|
Authors |
Mach, M, Schneider, U, Kersten, W, Mach, M., Schneider, U., Kersten, W. |
Abstract |
Evidence is presented showing a relation between polyamine concentration and the methylation of tRNA in vitro and in vivo. Polyamine excretion in urine of children with ALL and AML is slightly elevated before the commencement of chemotherapy. Immediately thereafter, excretion of acetylputrescine increases drastically over a period of at least 30-60 days. The elevation seems to be caused by different factors, e.g., destruction of tumor cells, induction of ornithindecarboxylase, and cell recovery after termination of chemotherapy. Acetylspermidine excretion also increases 3-4 days after the beginning of chemotherapy. A positive correlation exists between leukocyte counts and excretion of acetylspermidine. The ratio of acetylspermidine excretion at days 3-4 of the therapy to that before commencement of chemotherapy could be an indicator of response to the therapy. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 4 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Professor | 1 | 25% |
Researcher | 1 | 25% |
Other | 1 | 25% |
Unknown | 1 | 25% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 2 | 50% |
Unknown | 2 | 50% |