Chapter title |
From inflammation to neoplasia: new concepts in the pathogenesis of cutaneous lymphomas.
|
---|---|
Chapter number | 32 |
Book title |
Cancers of the Skin
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2002
|
DOI | 10.1007/978-3-642-59410-6_32 |
Pubmed ID | |
Book ISBNs |
978-3-64-263969-2, 978-3-64-259410-6
|
Authors |
Burg, Günter, Kempf, Werner, Haeffner, Andreas, Döbbeling, Udo, Nestle, Frank O, Böni, Roland, Kadin, Marshall, Dummer, Reinhard, Günter Burg, Werner Kempf, Andreas Haeffner, Udo Döbbeling, Frank O. Nestle, Roland Böni, Marshall Kadin, Reinhard Dummer, Nestle, Frank O. |
Abstract |
Mycosis fungoides is a clinicopathologic term which describes a neoplasm of cerebriform T lymphocytes that form plaques and tumors. We further suggest that mycosis fungoides arises in a background of chronic inflammation or as a response to chronic antigenic stimulation. Subsequently, a series of mutations results in the stepwise progression from eczematous patches, to plaques, tumors and eventual hematogenous dissemination. The pathogenetic process is driven by various, probably individually different, exogenous factors, e.g. environmental foreign antigens, bacterial superantigen, and/or endogenous factors, e.g. autocrine cytokine loops, CD40/CD40L and B7/CD28 interaction. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 11 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 3 | 27% |
Professor | 2 | 18% |
Researcher | 2 | 18% |
Student > Ph. D. Student | 2 | 18% |
Student > Doctoral Student | 1 | 9% |
Other | 0 | 0% |
Unknown | 1 | 9% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 6 | 55% |
Biochemistry, Genetics and Molecular Biology | 3 | 27% |
Immunology and Microbiology | 1 | 9% |
Unknown | 1 | 9% |