Chapter title |
HRT opposed to low-dose tamoxifen (HOT study): rationale and design.
|
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Chapter number | 10 |
Book title |
Tumor Prevention and Genetics
|
Published in |
Recent results in cancer research Fortschritte der Krebsforschung Progrès dans les recherches sur le cancer, January 2003
|
DOI | 10.1007/978-3-642-55647-0_10 |
Pubmed ID | |
Book ISBNs |
978-3-64-262892-4, 978-3-64-255647-0
|
Authors |
Decensi, Andrea, Galli, Arianna, Veronesi, Umberto, Andrea Decensi, Arianna Galli, Umberto Veronesi |
Abstract |
The rationale for the HOT study is mainly based on the findings of the Italian Tamoxifen Prevention Study, where 5,408 healthy hysterectomized women aged 35-70 years were randomized to 20 mg/day of tamoxifen or placebo for 5 years. After 81.2 months median follow-up, 79 breast cancers occurred (34 on tamoxifen versus 45 on placebo, p=0.215). In the subgroup of 1,580 women who used estrogen replacement therapy (ERT) at some point during the study, 23 breast cancers were observed: 17 on placebo and 6 on tamoxifen (hazard ratio=0.35, 95% CI, 0.14-0.89). Pharmacokinetic and pharmacodynamic (surrogate endpoint biomarkers) studies showed that a lower dose of tamoxifen (such as 5 mg/day) does not affect the drug's activity on several biomarkers of both cardiovascular and breast cancer risk. We therefore propose a multicenter placebo-controlled phase III trial in postmenopausal healthy women on hormone replacement therapy (HRT) to assess whether the combination of HRT and low-dose tamoxifen retains the benefits while reducing the risks of either. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 10 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Unspecified | 2 | 20% |
Student > Doctoral Student | 1 | 10% |
Student > Bachelor | 1 | 10% |
Student > Ph. D. Student | 1 | 10% |
Student > Master | 1 | 10% |
Other | 1 | 10% |
Unknown | 3 | 30% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 30% |
Unspecified | 2 | 20% |
Sports and Recreations | 1 | 10% |
Agricultural and Biological Sciences | 1 | 10% |
Unknown | 3 | 30% |