Chapter title |
Sodium calcium exchange as a target for antiarrhythmic therapy.
|
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Chapter number | 6 |
Book title |
Basis and Treatment of Cardiac Arrhythmias
|
Published in |
Handbook of experimental pharmacology, January 2006
|
DOI | 10.1007/3-540-29715-4_6 |
Pubmed ID | |
Book ISBNs |
978-3-54-024967-2, 978-3-54-029715-4
|
Authors |
Sipido, K R, Varro, A, Eisner, D, K.R. Sipido, A. Varro, D. Eisner, Sipido, K.R., Varro, A., Eisner, D. |
Abstract |
In search of better antiarrhythmic therapy, targeting the Na/Ca exchanger is an option to be explored. The rationale is that increased activity of the Na/Ca exchanger has been implicated in arrhythmogenesis in a number of conditions. The evidence is strong for triggered arrhythmias related to Ca2+ overload, due to increased Na+ load or during adrenergic stimulation; the Na/Ca exchanger may be important in triggered arrhythmias in heart failure and in atrial fibrillation. There is also evidence for a less direct role of the Na/Ca exchanger in contributing to remodelling processes. In this chapter, we review this evidence and discuss the consequences of inhibition of Na/Ca exchange in the perspective of its physiological role in Ca2+ homeostasis. We summarize the current data on the use of available blockers of Na/Ca exchange and propose a framework for further study and development of such drugs. Very selective agents have great potential as tools for further study of the role the Na/Ca exchanger plays in arrhythmogenesis. For therapy, they may have their specific indications, but they carry the risk of increasing Ca2+ load of the cell. Agents with a broader action that includes Ca2+ channel block may have advantages in other conditions, e.g. with Ca2+ overload. Additional actions such as block of K+ channels, which may be unwanted in e.g. heart failure, may be used to advantage as well. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 8 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Doctoral Student | 2 | 25% |
Student > Ph. D. Student | 1 | 13% |
Professor | 1 | 13% |
Unknown | 4 | 50% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 3 | 38% |
Agricultural and Biological Sciences | 1 | 13% |
Unknown | 4 | 50% |