You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Chapter title |
Inter-relationships between pterins and cytokines produced during allogeneic immune reactions and possible use as early markers of immune activation.
|
---|---|
Chapter number | 48 |
Book title |
Chemistry and Biology of Pteridines and Folates
|
Published in |
Advances in experimental medicine and biology, January 1993
|
DOI | 10.1007/978-1-4615-2960-6_48 |
Pubmed ID | |
Book ISBNs |
978-1-4613-6287-6, 978-1-4615-2960-6
|
Authors |
J. J. Rippin, D. C. Henderson, Rippin, J. J., Henderson, D. C. |
Abstract |
The pterins neopterin and xanthopterin have been measured together with the cytokines IFN-gamma, TNF-alpha and TNF-beta in the supernatants of 20 allogeneic mixed lymphocyte reactions. We have calculated rank correlation coefficients between these analytes and the immune response. Our findings confirm that neopterin is a sensitive early marker of immune activation and show that another pterin, xanthopterin could be used likewise. Cytokine production was also proportional to immune activation but none could be used consistently as early markers of immune activation. |